Neurological Sciences

, Volume 32, Supplement 1, pp 71–76 | Cite as

Disability in chronic daily headache: state of the art and future directions

  • Domenico D’AmicoEmail author
  • L. Grazzi
  • S. Usai
  • A. Raggi
  • M. Leonardi
  • G. Bussone
Symposium - Chronic Pain and Headache: New Legislation


Aim of this literature review is to summarize the most relevant research findings on disability in subjects with chronic daily headache (CDH) and chronic migraine (CM) measured with the MIDAS and the HIT-6, and to address issues for further research in the field. Research strategy aimed to find papers published after 2001 that focused on disability in patients with CDH, CM and transformed migraine. Both, general population surveys or clinical series were included if they reported total scores, or distribution of the different disability levels, derived from the MIDAS and/or from the HIT-6. Fifteen papers were selected. Studies demonstrated that these subjects report a remarkable impact on functioning, with high disability scores, and reduced ability in work and non-work activities. Modern definitions of disability conceptualize it as the result of the interaction between a health condition and environmental factors. Research strategies should therefore recognize that disability may represent a global evaluation which should be added to more specific endpoints, using instruments that measure disability in a multi-dimensional way, such as the WHO-DAS II.


Chronic daily headache (CDH) Chronic migraine Medication overuse (MO) MIDAS HIT-6 WHO-DAS II 


Conflict of interest

The authors declare that there is no actual or potential conflict of interest in relation to this article.


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Domenico D’Amico
    • 1
    Email author
  • L. Grazzi
    • 1
  • S. Usai
    • 1
  • A. Raggi
    • 2
  • M. Leonardi
    • 2
  • G. Bussone
    • 1
  1. 1.Headache Center, Neurological Institute “C. Besta” IRCCS FoundationMilanItaly
  2. 2.Neurology, Public Health and Disability Unit, Neurological Institute “C. Besta” IRCCS FoundationMilanItaly

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