Neurological Sciences

, Volume 32, Issue 4, pp 589–594

Effects of heating coagulation of middle meningeal artery on plasma CGRP level and c-fos expression in migraine rat triggered by nitroglycerin

  • Xiaofeng Zhu
  • Yuechen Han
  • Wenping Xiong
  • Wenwen Liu
  • Sumei Lu
  • Jianfeng Li
  • Haibo Wang
  • Zhaomin Fan
Original Article

DOI: 10.1007/s10072-011-0486-7

Cite this article as:
Zhu, X., Han, Y., Xiong, W. et al. Neurol Sci (2011) 32: 589. doi:10.1007/s10072-011-0486-7

Abstract

Current theory or hypothesis relevant to migraine indicates that trigeminovascular system plays a pivotal role in the pathophysiology of migraine. Particularly, release of neuropeptide and induction of c-fos like immunoreactivity (c-fos LI) within trigeminal nucleus caudalis neurons are regarded as activation markers of trigeminovascular system. In the present study, we set up a rat model for migraine triggered by nitroglycerin (NTG) and coagulated the middle meningeal artery by heating. Using this model, we determined the plasma calcitonin gene-related peptide (CGRP) level as well as the expression of c-fos in trigeminal nucleus caudalis of rats. We found that NTG led to markedly increase in plasma CGRP level and c-fos expression in trigeminal nucleus caudalis compared with the isotonic saline-treated group (P < 0.05). More importantly, heat coagulation of middle meningeal artery could decrease plasma CGRP level and c-fos expression in trigeminal nucleus caudalis (P < 0.05). Heat coagulation of middle meningeal artery may ameliorate sufferings of rat induced by NTG and play an important role in restraining the release of CGRP as well as the activation of neurons in trigeminal nucleus caudalis in rats following NTG infusion.

Keywords

Migraine Middle meningeal artery Trigeminal nucleus caudalis Calcitonin gene-related peptide C-fos 

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Xiaofeng Zhu
    • 1
  • Yuechen Han
    • 1
  • Wenping Xiong
    • 1
  • Wenwen Liu
    • 2
  • Sumei Lu
    • 2
  • Jianfeng Li
    • 2
  • Haibo Wang
    • 1
    • 2
  • Zhaomin Fan
    • 1
  1. 1.Otolaryngology-Head and Neck SurgeryProvincial Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  2. 2.Institute of Eye and ENTShandong Clinic Research InstituteJinanPeople’s Republic of China

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