Neurological Sciences

, Volume 32, Issue 5, pp 893–897 | Cite as

Medulloblastoma and gliomatosis cerebri: rare brain tumors in multiple sclerosis patients

  • Ana Alexandra Duarte Martins da SilvaEmail author
  • Sara Marta Pereira dos Santos Cavaco
  • Ricardo Jorge Ferreira Taipa
  • Pedro Ricardo Soares Pinto
  • Manuel Jorge Rocha Melo Pires
Case Report


The simultaneous appearance of both multiple sclerosis (MS) and central nervous system (CNS) tumors is relatively uncommon. Whether the co-existence of two diseases is due to chance alone or the result of a causal relationship is still a matter of debate. There is also controversy about the effect of long-term exposure of MS patients to immunomodulatory drugs on the incidence of cancer. This paper reports two cases of rare CNS tumors (i.e., medulloblastoma and gliomatosis cerebri) in adult MS patients. Our cases emphasize that when uncommon neurological features appear in patients with MS, brain magnetic resonance imaging (MRI) ought to be done and brain biopsy should be considered to exclude a concomitant CNS disorder. These procedures are essential for the differential diagnosis and early treatment.


MRI Multiple sclerosis Neuroimmunology Neurooncology Neuropathology 



We would like to acknowledge the contribution of Luis Monteiro, PhD, Elsa Silva and Isabel Ribeiro, MD (neurologist and neurosurgeon in our center). Dr. Heike Nesbit provided medical writing support for preparation of the manuscript on behalf of Merck Serono.

Conflict of interest



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Ana Alexandra Duarte Martins da Silva
    • 1
    Email author
  • Sara Marta Pereira dos Santos Cavaco
    • 2
  • Ricardo Jorge Ferreira Taipa
    • 1
  • Pedro Ricardo Soares Pinto
    • 3
  • Manuel Jorge Rocha Melo Pires
    • 4
  1. 1.Serviço de Neurologia, Largo do Prof Abel SalazarCentro Hospitalar do Porto/Hospital de Santo AntónioPortoPortugal
  2. 2.Departamento de Doenças do Sistema Nervoso e Orgãos dos SentidosUnidade de Neuropsicologia, Centro Hospitalar do Porto/Hospital de Santo AntónioPortoPortugal
  3. 3.Servico de NeurorradiologiaCentro Hospitalar do Porto/Hospital de Santo AntónioPortoPortugal
  4. 4.Unidade de NeuropatologiaCentro Hospitalar do Porto/Hospital de Santo AntónioPortoPortugal

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