Investigation of the prevalence of antibodies against neurotropic polyomaviruses BK, JC and SV40 in sera from patients affected by multiple sclerosis
- 149 Downloads
Viral agents seem to be linked to multiple sclerosis (MS). This association is based on evidence of (1) early exposure to viruses and MS onset; (2) increased prevalence of MS disease in specific geographic regions; (3) likelihood of developing MS being more prevalent in high-risk areas; (4) altered immune responses to different viruses. In this study, sera from patients affected by MS and controls, represented by sera from patients with other neurologic diseases, both inflammatory and non-inflammatory, and from healthy donors, were investigated for the presence of antibodies against neurotropic polyomaviruses BKV, JCV and SV40 in their sera. Our study has indicated that the prevalence of BKV antibodies in sera from MS patients is higher than that detected in normal individuals, while levels of antibodies against BKV and JCV are lower in MS patients compared to those of normal subjects.
KeywordsMultiple sclerosis Polyomaviruses Inflammatory diseases Non-inflammatory diseases
This work was supported, in parts, by grants from The University of Ferrara, FAR Projects and Regione Emilia Romagna, MS project to E.G., F.M. and M.T., Fondazione Cassa di Risparmio di Ferrara to E.G., and Fondazione Cassa di Risparmio di Cento to F.M. and M.T. Italy.
- 2.Granieri E (1997) The epidemiology study of exogenous factors in the etiology of multiple sclerosis. Introduction. Neurology 49:S2–S4Google Scholar