Neurological Sciences

, Volume 31, Supplement 3, pp 321–323 | Cite as

Natalizumab efficacy on cognitive impairment in MS

Session III – Natalizumab: Update on New Clinical and Radiological Evidence


We report follow-up data on the efficacy of natalizumab therapy on neuropsychological impairment on an italian MS group of 39 patients at 1 year and of 11 patients at 2 years. Results show a significant reduction in relapse rate, in the number of impaired neuropsychological tests as well as in several single executive function and reasoning tests scores at 1 year. Improvement persisted at 2 years, including also memory and speed processing tasks. These data support the efficacy of natalizumab therapy in all the clinical domains, including cognitive deterioration, in multiple sclerosis patients.


Natalizumab Cognitive impairment Multiple sclerosis 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • F. Mattioli
    • 1
  • C. Stampatori
    • 1
  • F. Bellomi
    • 1
  • R. Capra
    • 2
  1. 1.Neuropsychology UnitSpedali Civili of BresciaBresciaItaly
  2. 2.Multiple Sclerosis CenterSpedali Civili of BresciaBresciaItaly

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