Neurological Sciences

, Volume 31, Issue 6, pp 871–872 | Cite as

Antibodies to aquaporin-4 in non-small cell lung cancer: a study on 50 patients

  • S. Jarius
  • A. Warth
  • K. P. Wandinger
  • P. A. Schnabel
  • H. Hoffmann
  • B. WildemannEmail author
  • T. Muley
Letter to the Editor

Dear Editor,

Neuromyelitis optica (NMO) is an aetiologically heterogeneous chronic inflammatory disorder of the CNS that predominantly affects the optic nerves and spinal cord [1]. NMO is associated with the presence of serum antibodies to aquaporin-4 (AQP4-Ab, also called NMO-IgG), the most abundant water channel in the CNS [2, 3].

Recently, De Santis et al. [4] reported on a patient with AQP4-Ab positive NMO and non-small cell lung cancer (NSCLC). Whether, NMO occurred independently in that patient or was linked to the presence of NSCLC is unknown. However, the association of AQP4-Ab and NSCLC in that case is intriguing, for AQP4 is expressed constitutively in ~40% of all NSCLC carcinomas (Warth et al., unpublished observation). AQP4-Ab may thus be produced as a part of the tumour immune response in some cases.

We were therefore interested in whether AQP4-Ab seropositive status is common among patients with NSCLC. The lack of neurological disease in the vast majority of NSCLC...


AQP4 Expression Neuromyelitis Optica Small Cell Lung Cancer Patient Pleomorphic Carcinoma Positive Control Seron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The work of S.J. was supported by a Research Fellowship from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and by research grants from Merck Serono and Bayer Schering Pharma. The work of A.W. was supported by a grant of the Monika Kutzner-Stiftung and the PostDoc program of the Medical Faculty, University of Heidelberg. We are thankful to Brigitte Fritz, Maria Eschlbeck, and to the Nikon Imaging Center at the University of Heidelberg for excellent technical assistance.

Conflict of interest

The authors have reported that they have no conflict of interest.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • S. Jarius
    • 1
  • A. Warth
    • 2
  • K. P. Wandinger
    • 3
    • 4
  • P. A. Schnabel
    • 2
  • H. Hoffmann
    • 5
  • B. Wildemann
    • 1
    Email author
  • T. Muley
    • 6
  1. 1.Division of Molecular Neuroimmunology, Department of NeurologyUniversity of HeidelbergHeidelbergGermany
  2. 2.Institute of PathologyUniversity of HeidelbergHeidelbergGermany
  3. 3.Institute for Experimental Immunology Affiliated to EuroimmunLuebeckGermany
  4. 4.Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology Hamburg (ZMNH)University Medical Center EppendorfHamburgGermany
  5. 5.Translational Research UnitThoraxklinik HeidelbergHeidelbergGermany
  6. 6.Department of Thoracic SurgeryThoraxklinik HeidelbergHeidelbergGermany

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