Neurological Sciences

, Volume 31, Issue 6, pp 807–811 | Cite as

Long survival and clinical stability in Marburg’s variant multiple sclerosis

  • Marco Turatti
  • Alberto Gajofatto
  • Francesca Rossi
  • Marcella Vedovello
  • Maria Donata Benedetti
Case Report

Abstract

Marburg’s variant multiple sclerosis (MS) is an acute and aggressive atypical form of MS, leading frequently to death in few months. A 32-year-old man with motor and sensory symptoms suggestive of acute myelopathy, rapidly followed by cerebellar dysfunction and consciousness impairment. Clinical, laboratory and radiological evaluations suggested a central nervous system demyelinating disease. The diagnosis was Marburg’s variant MS, usually leading to death in short time. He underwent different treatments, including steroids, cyclophosphamide, plasma exchange and lastly interferon-beta. The patient reached clinical stability with severe residual disability, persistent after 3 years from onset. This observation suggests that subjects with Marburg’s MS might reach long clinical stability.

Keywords

Long survival Marburg’s variant Multiple sclerosis 

References

  1. 1.
    Marburg O (1906) Die Sogennate “Acute Multiple Sclerosis” (encephalomyelitis pariaxialis scleroticans). Jahrl Psychiat Neurol 27:213–311Google Scholar
  2. 2.
    Krupp LB, Banwell B, Tenembaum S (2007) Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurology 68(Suppl 2):S7–S12CrossRefPubMedGoogle Scholar
  3. 3.
    Giubilei F, Sarrantonio A, Tisei P, Gasperini C, Salvetti M (1997) Four-year follow-up of a case of acute multiple sclerosis of the Marburg type. Ital J Neurol Sci 18:163–166CrossRefPubMedGoogle Scholar
  4. 4.
    Jeffery DR, Lefkowitz DS, Crittenden JP (2004) Treatment of Marburg variant multiple sclerosis with mitoxantrone. J Neuroimaging 14:58–62PubMedGoogle Scholar
  5. 5.
    Jasperson J, Jones AG (1998) A case of rapid deterioration: acute multiple sclerosis of the Marburg type. J Neurosci Nurs 30:350–351CrossRefPubMedGoogle Scholar
  6. 6.
    Mendez MF, Pogacar S (1988) Malignant monophasic multiple sclerosis or “Marburg’s disease”. Neurology 38(7):1153–1155PubMedGoogle Scholar
  7. 7.
    Johnson MD, Lavin P, Whetsell WO Jr (1990) Fulminant monophasic multiple sclerosis, Marburg’s type. J Neurol Neurosurg Psychiatry 53:918–921CrossRefPubMedGoogle Scholar
  8. 8.
    Wood DD, Bilbao JM, O’Connors P (1996) Acute multiple sclerosis (Marburg type) is associated with developmentally immature myelin basic protein. Ann Neurol 40(1):18–24CrossRefPubMedGoogle Scholar
  9. 9.
    Gonzàles Sàanchez J, Ensenyat Nora J, de Notaris M, Rumia Arboix J, Garcia-Amorena Garcia C, Ferrer Rodriguez E (2008) A case of malignant monophasic multiple sclerosis (Marburg’s disease type) successfully treated with decompressive hemicraniectomy. J Neurol Neurosurg PsychiatryGoogle Scholar
  10. 10.
    Letournel F, Cassereau J, Scherer-Gagou C, Bernard I, Mercat A, Gray F et al (2008) An autopsy of acute multiple sclerosis (Marburg’s type) during pregnancy. Clin Neurol Neurosurg 110:514–517CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Marco Turatti
    • 1
  • Alberto Gajofatto
    • 1
  • Francesca Rossi
    • 1
  • Marcella Vedovello
    • 1
  • Maria Donata Benedetti
    • 1
  1. 1.Section of Neurology, Department of Neurological and Vision SciencesUniversity of VeronaVeronaItaly

Personalised recommendations