Neurological Sciences

, Volume 31, Issue 5, pp 565–569 | Cite as

Effect of entacapone on plasma homocysteine levels in Parkinson’s disease patients

  • Martin Nevrly
  • Petr Kanovsky
  • Hana Vranova
  • Katerina Langova
  • Petr Hlustik
Original Article


Peripheral metabolism of l-DOPA via enzyme catechol-O-methyltransferase (COMT) is one of the possible sources of homocysteine (HCY). The aim of this study was to assess plasma HCY levels in l-DOPA-treated Parkinson’s disease (PD) patients and its influence by adding the inhibitor COMT (entacapone). Patients were divided into two groups: (1) patients long term treated with l-DOPA but were naïve to entacapone, (2) l-DOPA naïve patients, in whom a combined treatment with l-DOPA and entacapone was started. The HCY levels were higher in Group 1 than in Group 2. No statistically significant changes of HCY concentrations were found in both patient groups after adding entacapone to their l-DOPA treatments. Results of this study confirm that patients treated with l-DOPA for a long term have increased plasma HCY concentrations. We believe combined l-DOPA and entacapone therapy could be a possible protective mechanism against hyperhomocysteinemia in early PD.


Homocysteine Parkinson’s disease Entacapone 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Martin Nevrly
    • 1
  • Petr Kanovsky
    • 1
  • Hana Vranova
    • 1
  • Katerina Langova
    • 2
  • Petr Hlustik
    • 1
  1. 1.Department of NeurologyUniversity Hospital and Palacký University Medical SchoolOlomoucCzech Republic
  2. 2.Department of BiophysicsPalacký University Medical SchoolOlomoucCzech Republic

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