Neurological Sciences

, Volume 31, Issue 5, pp 531–540

Parkinson’s disease: oxidative stress and therapeutic approaches

Review Article


Parkinson’s disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin–proteasome pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.


Parkinson’s disease Antioxidant Withania somnifera Neurodegeneration Canavan disease 

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.School of MedicineLSUHSCNew OrleansUSA
  2. 2.Department of AnatomyMelmaruvathur Adhi Parasakthi Institute of Medical SciencesMelmaruvathurIndia

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