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Neurological Sciences

, Volume 31, Issue 1, pp 29–33 | Cite as

The first case history of multiple sclerosis: Augustus d’Esté (1794–1848)

  • Anne-Marie Landtblom
  • Patrik Fazio
  • Sten Fredrikson
  • Enrico Granieri
Original Article

Abstract

The personal diary of Sir Augustus d’Esté, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease. Charcot coined the term sclérose en plaques 20 years after the death of this patient in 1848. The onset of this man’s MS seems to have been in 1822 with bilateral optic neuritis, the disease gradually developing in the classic manner with bouts derived from different loci in the central nervous system and eventually a secondary progressive form with paraparesis, sphincter incontinence, urinary problems and impotence. In 1941, Firth highlighted the case of Augustus d’Esté and later wrote a description of the pathology including a discussion on the aetiology of MS. No previous medical records have given such a characteristic picture of MS as this.

Keywords

Multiple sclerosis Medical history Case report 

References

  1. 1.
    Granieri E (2006) La malattia di Augusto d’Este. A un discendente degli Estensi si deve la prima testimonianza sulla sclerosi multipla. Ferrara Voci di una Città 25:3539Google Scholar
  2. 2.
    Firth D (1941) The case of Augustus d’Estè (1794–1848): the first account of disseminated sclerosis. Proc R Soc Med 34:381–384PubMedGoogle Scholar
  3. 3.
    Firth D (1948) The case of Augustus d’Esté. Cambridge University Press, CambridgeGoogle Scholar
  4. 4.
    Fredrikson S, Kam-Hansen S (1989) The 150-year anniversary of multiple sclerosis: does its early history give an etiological clue? Perspect Biol Med 32(2):237–243PubMedGoogle Scholar
  5. 5.
    Compston A, Lassman H, McDonald I (2006) The story of multiple sclerosis. In: McAlpines multiple sclerosis, 4th edn. Churchill Livingstone/Elsevier, LondonGoogle Scholar
  6. 6.
    Landtblom AM, Granieri E, Fredrikson (2007) The first documented case of multiple sclerosis—Augustus d’Este. Läkartidningen (Swedish Phys J) 26–27:2009–2011Google Scholar
  7. 7.
    Romberg MH (1846) Lehrbuch der Nervenkrankheiten. BerlinGoogle Scholar
  8. 8.
    Charcot JM (1868) Histologie de la sclérose en plaques. Gaz. des hospitaux 41:554–555, 557–558, 566Google Scholar
  9. 9.
    Cruveilhier J (1829–1842) Anatomie pathologique du corps humain ou descriptions avec figures lithographiées et coloriées des diverses altérations morbides dont le corps humain est susceptible. Bailliere, ParisGoogle Scholar
  10. 10.
    Putnam TJ (1938) The centenary of multiple sclerosis. Arch Neurol Psych 40:806–813Google Scholar
  11. 11.
    Frerich FT (1849) Ueber Hirnsklerose. Arch Ges Med 10:334–350Google Scholar
  12. 12.
    Valentiner W (1856) Ueber die Sklerose des Gehirns und Ruckenmarks. Dtsch Klein 8:147, 158, 167Google Scholar
  13. 13.
    Bourneville DM, Guerard L (1869) De la sclérose en plaques disséminées. Delahage, ParisGoogle Scholar
  14. 14.
    Sherwin AL (1957) Multiple sclerosis in historical perspective. McGill Med J 26:39–48PubMedGoogle Scholar
  15. 15.
    Granieri E, Casetta I (1997) Selected reviews on common childhood and adolescent infections and multiple sclerosis. Neurology Suppl:S42–S54Google Scholar
  16. 16.
    Li J, Johansen C, Brönnum-Hansen H, Stenager E, Koch-Henriksen N, Olsen J (2004) The risk of multiple sclerosis in bereaved parents: a nationwide cohort study in Denmark. Neurology 5:726–729Google Scholar
  17. 17.
    Marie P (1884) Sclérose en plaques et maladies infectieuses. Progr Med Paris 12:287–289, 305–307, 349–351, 365–366Google Scholar
  18. 18.
    Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Anne-Marie Landtblom
    • 1
  • Patrik Fazio
    • 2
  • Sten Fredrikson
    • 3
  • Enrico Granieri
    • 2
  1. 1.Division of NeurologyLinköping University HospitalLinköpingSweden
  2. 2.Department of Neurology, Multiple Sclerosis CentreFerrara UniversityFerraraItaly
  3. 3.Department of NeurologyKarolinska InstituteStockholmSweden

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