Neurological Sciences

, Volume 31, Issue 2, pp 125–131 | Cite as

Reversible posterior leukoencephalopathy syndrome in childhood: report of nine cases and review of the literature

  • Hakan GümüşEmail author
  • Hüseyin Per
  • Sefer Kumandaş
  • Ali Yıkılmaz
Original Article


Reversible posterior leukoencephalopathy syndrome (RPLS) is recently described disorder with typical radiological findings in the posterior regions of the cerebral hemisphere and cerebellum. Its clinical symptoms include headache, decreased alertness, mental abnormalities, such as confusion, diminished spontaneity of speech, and changed behavior ranging from drowsiness to stupor, seizures, vomiting and abnormalities of visual perception like cortical blindness. RPLS is caused by various heterogeneous factors, the commonest being hypertension, followed by non-hypertensive causes such as eclampsia, renal diseases and immunosuppressive therapy. We presented nine patients with RPLS who had primary diagnoses such as acute post-streptococcal glomerulonephritis, idiopathic hypertension, the performing of intravenous immunoglobulin for infection with crescentic glomerulonephritis, erythrocyte transfusion for severe iron deficiency, l-asparaginase treatment for acute lymphoblastic leukemia and performing of granulocyte-colony stimulating factor for ulcerative colitis due to neutropenia. Early recognition of RPLS as complication during different diseases and therapy in childhood may facilitate precise diagnosis and appropriate treatment.


Reversible posterior leukoencephalopathy syndrome Childhood Granulocyte-colony stimulating factor 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Hakan Gümüş
    • 1
    Email author
  • Hüseyin Per
    • 1
  • Sefer Kumandaş
    • 2
  • Ali Yıkılmaz
    • 3
  1. 1.Department of Pediatric NeurologyKayseri Education and Research HospitalTalasTurkey
  2. 2.Department of Pediatric NeurologyErciyes University Medical FacultyKayseriTurkey
  3. 3.Department of Pediatric RadiologyErciyes University Medical FacultyKayseriTurkey

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