Neurological Sciences

, Volume 30, Issue 4, pp 361–364 | Cite as

Blood levels of homocysteine, cysteine, glutathione, folic acid, and vitamin B12 in the acute phase of atherothrombotic stroke

  • Giuseppe Salemi
  • M. C. Gueli
  • M. D’Amelio
  • V. Saia
  • P. Mangiapane
  • P. Aridon
  • P. Ragonese
  • I. Lupo
Brief Communication


Blood levels of total homocysteine (tHcy), cysteine (Cys), total and reduced glutathione (tGSH and rGSH), folic acid (FA), and vitamin B12 (B12) change during ischemic stroke as accompaniment of the tissue damage. The relationship between these changes remains scantly investigated. We evaluated the variation of these molecules in the 48 h after acute large artery atherothrombotic stroke (LAAS) and searched for the presence of matched variation of them. The study involved 50 subjects affected by acute LAAS and 49 healthy controls. Plasma levels of tHcy and Cys were significantly higher and serum levels of FA and B12 and plasma levels of rGSH were significantly lower in the patients than in the control group. Acute LAAS was associated with increased Hcy—decreased tGSH and decreased FA/tGSH. Pathways involved in cellular stress and in tissue repair are activated during acute LAAS.


Large artery atherothrombotic stroke Homocysteine Cysteine Folic acid Vitamin B12 Reduced glutathione 


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Giuseppe Salemi
    • 1
  • M. C. Gueli
    • 2
  • M. D’Amelio
    • 1
  • V. Saia
    • 1
  • P. Mangiapane
    • 1
  • P. Aridon
    • 1
  • P. Ragonese
    • 1
  • I. Lupo
    • 1
  1. 1.Section of Neurology, Department of Clinical NeuroscienceUniversity of PalermoPalermoItaly
  2. 2.Department of Biochemical SciencesUniversity of PalermoPalermoItaly

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