Advertisement

Neurological Sciences

, Volume 30, Issue 2, pp 153–158 | Cite as

RETRACTED ARTICLE: The sequential magnetic resonance images of tri-methyl tin leukoencephalopathy

  • Chang Ho HwangEmail author
Case Report

Abstract

Organotin compounds are commonly used in industrial and agriculture. It causes toxic effects on skin, eyes, respiratory system, gastrointestinal system, and nervous system. After cleaning a di-methyl tin tank, 43-year-old man showed a dizziness, disorientation, visual hallucination, and agitation. Through a measurement by liquid chromatography and inductively coupled plasma-mass spectrometry, di-methyl tin and tri-methyl tin was detected. Although magnetic resonance (MR) image 3 days after exposure showed no abnormal signal intensity, follow-up MR images 15 days after exposure revealed abnormal extensive signal intensities in the white matter that was not ever coincident with previous reports. It was hardly explainable that previous abnormal signal intensities of MR image nearly disappeared 4 months later. We present a case of a patient who developed acute toxic leukoencephalopathy from an acute inhalational exposure to methyl tin with sequential MR images showing an involvement of white matter that was not ever reported.

Keywords

Intoxication Tin Magnetic resonance imaging Leukoencephalopathy 

Notes

Acknowledgments

No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated.

References

  1. 1.
    Aldridge WN, Brown AW, Brierley JB, Verschoyle RD, Street BW (1981) Brain damage due to trimethyl tin compounds. Lancet 2:692–693PubMedCrossRefGoogle Scholar
  2. 2.
    Barnes JM, Stoner HB (1959) The toxicology of tin compounds. Pharmacol Rev 11:211–231PubMedGoogle Scholar
  3. 3.
    Besser R, Kramer G, Thumler R, Bohl J, Gutmann L, Hopf HC (1987) Acute trimethyltin limbic-cerebellar syndrome. Neurology 37:945–950PubMedGoogle Scholar
  4. 4.
    Bouldin TW, Goines ND, Bagnell RC, Krigman MR (1981) Pathogenesis of trimethyltin neuronal toxicity. Ultrastructural and cytochemical observations. Am J Pathol 104:237–249PubMedGoogle Scholar
  5. 5.
    Brown AW, Aldridge WN, Street BW, Verschoyle RD (1979) The behavioral and neuropathologic sequelae of intoxication by trimethyltin compounds in the rat. Am J Pathol 97:59–82PubMedGoogle Scholar
  6. 6.
    Brown AW, Verschoyle RD, Street BW, Aldridge WN, Grindley H (1984) The neurotoxicity of trimethyltin chloride in hamsters, gerbils and marmosets. J Appl Toxicol 4:12–21PubMedCrossRefGoogle Scholar
  7. 7.
    Chang LW (1990) The neurotoxicology and pathology of organomercury, organolead, and organotin. J Toxicol Sci 15(Suppl 4):125–151PubMedCrossRefGoogle Scholar
  8. 8.
    Ebisu T, Naruse S, Horikawa Y, Ueda S, Tanaka C, Uto M, Umeda M, Higuchi T (1993) Discrimination between different types of white matter edema with diffusion-weighted MR imaging. J Magn Reson Imaging 3:863–868PubMedCrossRefGoogle Scholar
  9. 9.
    Feldman RG, White RF, Eriator II (1993) Trimethyltin encephalopathy. Arch Neurol 50:1320–1324PubMedCrossRefGoogle Scholar
  10. 10.
    Fortemps E, Amand G, Bomboir A, Lauwerys R, Laterre EC (1978) Trimethyltin poisoning. Report of two cases. Int Arch Occup Environ Health 41:1–6PubMedCrossRefGoogle Scholar
  11. 11.
    Grunner J (1958) Damage to the central nervous system after ingestion of an ethyl tin compound(Stalinon). Rev Neurol (Paris) 98:106–109Google Scholar
  12. 12.
    Gui-bin J, Qun-fang Z, Bin H (2000) Tin compounds and major trace metal elements in organotin-poisoned patient’s urine and blood measured by gas chromatography-flame photometric detector and inductively coupled plasma-mass spectrometry. Bull Environ Contam Toxicol 65:277–284PubMedCrossRefGoogle Scholar
  13. 13.
    Kreyberg S, Torvik A, Bjorneboe A, Wiik-Larsen W, Jacobsen D (1992) Trimethyltin poisoning: report of a case with postmortem examination. Clin Neuropathol 11:256–259PubMedGoogle Scholar
  14. 14.
    Krigman MR, Silverman AP (1984) General toxicology of tin and its organic compounds. Neurotoxicology 5:129–139PubMedGoogle Scholar
  15. 15.
    Perretta G, Righi FR, Gozzo S (1993) Neuropathological and behavioral toxicology of trimethyltin exposure. Ann Ist Super Sanita 29:167–174PubMedGoogle Scholar
  16. 16.
    Piver WT (1973) Organotin compounds: industrial applications and biological investigation. Environ Health Perspect 4:61–79PubMedCrossRefGoogle Scholar
  17. 17.
    Reiter LW, Ruppert PH (1984) Behavioral toxicity of trialkyltin compounds: a review. Neurotoxicology 5:177–186PubMedGoogle Scholar
  18. 18.
    Yanofsky NN, Nierenberg D, Turco JH (1991) Acute short-term memory loss from trimethyltin exposure. J Emerg Med 9:137–139PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Physical Medicine and Rehabilitation, Ulsan University HospitalUniversity of Ulsan College of MedicineUlsanKorea

Personalised recommendations