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Neurological Sciences

, 29:275 | Cite as

Excessive blinking as an initial manifestation of juvenile Huntington’s disease

  • Shihui Xing
  • Ling Chen
  • Xi Chen
  • Zhong Pei
  • Jinsheng Zeng
  • Jinru Li
Case Report

Abstract

Juvenile Huntington’s disease (JHD) is mostly characterized by rigidity, myoclonus, bradykinesia, dystonia and seizure. We report a 9-year-old male JHD patient presenting excessive blinking as the initial symptom two years prior to typical JHD symptoms. Genetic analysis revealed expansion of 108 CAG repeats and magnetic resonance imaging showed caudate atrophy with lateral ventricular enlargement.

Keywords

Blinking Juvenile Huntington’s disease CAG repeats 

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Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Shihui Xing
    • 1
    • 2
  • Ling Chen
    • 1
    • 2
  • Xi Chen
    • 3
  • Zhong Pei
    • 1
    • 2
  • Jinsheng Zeng
    • 1
    • 2
  • Jinru Li
    • 1
  1. 1.Department of NeurologyFirst Affiliated Hospital, Sun Yat-Sen UniversityGuangzhouChina
  2. 2.Stroke CenterFirst Affiliated Hospital, Sun Yat-Sen UniversityGuangzhouChina
  3. 3.Department of RehabilitationFirst Affiliated Hospital, Sun Yat-Sen UniversityGuangzhouChina

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