Neurological Sciences

, 29:237 | Cite as

Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study

  • Barbara Mostacci
  • Monica Ferlisi
  • Alessandro Baldi Antognini
  • Claudia Sama
  • Cristina Morelli
  • Susanna Mondini
  • Fabio Cirignotta
Original Article


Sleep disturbance and excessive daytime sleepiness have been reported in patients with hepatic cirrhosis. The objective of this study was to evaluate daytime somnolence and sleep complaints in a group of 178 patients with cirrhosis compared to a control group. Sleep features and excessive daytime sleepiness were evaluated by the Basic Nordic Sleep Questionnaire (BNSQ) and the Epworth Sleepiness Scale (ESS). We collected clinical and laboratory data, neurological assessment and EEG recordings in cirrhotic patients. Patients with cirrhosis complained of more daytime sleepiness (p<0.005), sleeping badly at least three times a week (p<0.005), difficulties falling asleep (p<0.01) and frequent nocturnal awakening (p<0.005) than controls. We found a poor correlation between sleep disorders and clinical or laboratory parameters. Our results confirm previous literature reports suggesting a high prevalence of sleep disturbance in patients with cirrhosis. Insomnia and daytime sleepiness are the main complaints. Sleep disorders are probably a multifactorial phenomenon.


Liver cirrhosis Insomnia Daytime somnolence 


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Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Barbara Mostacci
    • 1
  • Monica Ferlisi
    • 1
  • Alessandro Baldi Antognini
    • 2
  • Claudia Sama
    • 3
  • Cristina Morelli
    • 3
  • Susanna Mondini
    • 1
  • Fabio Cirignotta
    • 1
  1. 1.Neurology UnitS. Orsola-Malpighi HospitalBolognaItaly
  2. 2.Department of Statistical SciencesUniversity of BolognaBolognaItaly
  3. 3.Department of Internal Medicine S. Orsola-Malpighi HospitalUniversity of BolognaBolognaItaly

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