Interferon-beta responders and non-responders. A biological approach
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- Bertolotto, A. & Gilli, F. Neurol Sci (2008) 29(Suppl 2): 216. doi:10.1007/s10072-008-0941-2
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The therapeutic benefits of interferon-beta are limited, as some patients with multiple sclerosis (MS) do not respond to therapy. Based on their biological characteristics, non-responsive patients can be divided into three subgroups: genetic, pharmacological and pathogenetic non-responders. In order to tailor the best treatment in both newly diagnosed MS patients and those already receiving treatment, the neurologist must carefully consider the risk of treating non-responders.