Neurological Sciences

, Volume 29, Supplement 1, pp 173–175

Homocysteine plasma levels in patients with migraine with aura

  • Franca Moschiano
  • Domenico D’Amico
  • Susanna Usai
  • Licia Grazzi
  • Maria Di Stefano
  • Emilio Ciusani
  • Nicoletta Erba
  • Gennaro Bussone
Oral Communication

Abstract

We investigated homocysteine plasma levels in 136 MA sufferers and in 117 sex-and age-matched controls. Mean homocysteine plasma levels — as well as the proportion of subjects with hyperhomocysteinaemia — were significantly higher in patients with MA than in healthy controls. Hyperhomocysteinaemia may be a link between MA and ischaemic stroke.

Keywords

Migraine with aura (MA) Homocysteine Hyperhomocysteinaemia Stroke 

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References

  1. 1.
    Swartz RH, Kern RZ (2004) Migraine is associated with magnetic resonance imaging white abnormalities: a meta-analysis. Arch Neurol 61:1366–1368PubMedCrossRefGoogle Scholar
  2. 2.
    Kruit MC, van Buchem MA, Hofman PA et al (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434PubMedCrossRefGoogle Scholar
  3. 3.
    Schwaag S, Nabavi DG, Frese A et al (2003) The association between migraine and juvenile stroke: a case-control study. Headache 43:90–95PubMedCrossRefGoogle Scholar
  4. 4.
    Merikangas KR, Fenton BT, Cheng SH et al (1997) Association between migraine and stroke in a large-scale epidemiological study of the United States. Arch Neurol 54:362–368PubMedGoogle Scholar
  5. 5.
    Scher AJ, Terwind GM, Picaves HSJ et al (2005) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620PubMedGoogle Scholar
  6. 6.
    Bautista LE, Arenas IA, Peñuela A, Martínez LX (2002) Total plasma homocysteine level and risk of cardiovascular disease: a meta-analysis of prospective cohort studies. J Clin Epidemiol 55:882–887PubMedCrossRefGoogle Scholar
  7. 7.
    Casas JP, Bautista LE, Smeeth L et al (2005) Homocysteine and stroke; evidence on causal link from mendelian randomisation. Lancet 365:224–232PubMedGoogle Scholar
  8. 8.
    — (2007) SPREAD — Stroke Prevention And Educational Awareness Diffusion. Ictus cerebrale: Linee Guida Italiane (5 edizione, 20 dicembre)Google Scholar
  9. 9.
    Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015–2022CrossRefGoogle Scholar
  10. 10.
    Headache Classification Subcommittee of the International Headache Society (2004) The International Classification of Headache Disorders, 2nd edn. Cephalalgia 24[Suppl 1]:1–160Google Scholar
  11. 11.
    Hering-Hanit R, Gadoth N, Yavetz A et al (2001) Is blood homocysteine elevated in migraine? Headache 41:779–781PubMedCrossRefGoogle Scholar
  12. 12.
    Evers S, Koch HG, Suhr B, Husstedt IW (1998) Increased homocysteine level in migraine with aura. Eur J Neurol 5[Suppl 3]:S51–S52Google Scholar
  13. 13.
    Kowa H, Yasui K, Takeshima T et al (2000) The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine. Am J Med Gener 96:762–764CrossRefGoogle Scholar
  14. 14.
    Lea RA, Ovcaric M, Sundholm J et al (2004) The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura. BMC Med 2:3PubMedCrossRefGoogle Scholar
  15. 15.
    Kara I, Sazci A Ergul E et al (2003) Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. Brain Res Mol Brain Res 111:84–90PubMedCrossRefGoogle Scholar
  16. 16.
    Oterino A, Valle N (2004) MTHFR T677 homozygosis influences the presence of aura in migraineurs. Cephalalgia 24:491–494PubMedCrossRefGoogle Scholar
  17. 17.
    Scher AI, Terwindt G, Verschuren WM et al (2006) Migraine and MTHFR C677T genotype in a population-based sample. Ann Neurol 59:372–375PubMedCrossRefGoogle Scholar
  18. 18.
    Dreier JP, Kleeberg J, Petzold G et al (2002) Endothelin-1 potently induces Leao’s cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura? Brain 125:102–112PubMedCrossRefGoogle Scholar
  19. 19.
    Splaver A, Lamas GA, Hennekens CH (2004) Homocysteine and cardiovascular disease: biological mechanisms, observational epidemiology, and need for randomized trials. Am Heart J 148: 34–40PubMedCrossRefGoogle Scholar
  20. 20.
    Hadjikhani N, Sanchez Del Rio M, Wu O et al (2001) Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A 98:4687–4692PubMedCrossRefGoogle Scholar
  21. 21.
    Goldstein LB, Adams R, Alberts MJ et al (2006) Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council. Stroke 37:1583–1633PubMedGoogle Scholar
  22. 22.
    Toole JF, Malinow MR, Chambless LE et al (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death; the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291:565–575PubMedCrossRefGoogle Scholar
  23. 23.
    Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators (2006) Homocysteine lowering with folic acid and vitamins in vascular disease. N Engl J Med 354:1567–1577CrossRefGoogle Scholar
  24. 24.
    Bonaa KH, Njolstad I, Ueland PM et al (2006) NORVIT Trial Investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354:1578–1588.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2008

Authors and Affiliations

  • Franca Moschiano
    • 1
    • 2
  • Domenico D’Amico
    • 4
  • Susanna Usai
    • 4
  • Licia Grazzi
    • 4
  • Maria Di Stefano
    • 2
  • Emilio Ciusani
    • 4
  • Nicoletta Erba
    • 3
  • Gennaro Bussone
    • 4
  1. 1.L. Mandic HospitalMerate (LC)Italy
  2. 2.Headache Centre Merate HospitalA.O. “Ospedale di Lecco”LeccoItaly
  3. 3.Department of Laboratory MedicineMerate Hospital — A.O. “Ospedale di Lecco”LeccoItaly
  4. 4.Headache CentreNeurological Institute C. Besta IRCCSMilanItaly

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