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Neurological Sciences

, Volume 27, Issue 2, pp 118–121 | Cite as

Creutzfeldt-Jakob disease presenting as corticobasal degeneration: a neurophysiological study

  • L. Avanzino
  • L. Marinelli
  • A. Buccolieri
  • C. Trompetto
  • G. Abbruzzese
CASE REPORT

Abstract

Creutzfeldt-Jakob disease (CJD) can occasionally present with a clinical picture resembling a corticobasal degeneration (CBD). Transcallosal inhibition, as tested by focal transcranial magnetic stimulation, is frequently absent or highly disrupted in CBD patients. We report a case of CJD presenting at the beginning of the disease as a CBD in which the ipsilateral silent period (iSP) was present and well detectable. This brief report shows that study of the iSP may be a useful diagnostic tool in order to differentiate CBD from syndromes presenting with similar clinical features.

Key words

Creutzfeldt-Jakob disease Corticobasal degeneration Transcranial magnetic stimulation Transcallosal inhibition 

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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • L. Avanzino
    • 1
  • L. Marinelli
    • 1
  • A. Buccolieri
    • 1
  • C. Trompetto
    • 1
  • G. Abbruzzese
    • 1
  1. 1.Department of Neurosciences, Ophthalmology & GeneticsUniversity of GenoaGenoaItaly

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