Neurological Sciences

, Volume 26, Issue 4, pp 255–262

Psychiatric disorders and depression in multiple sclerosis outpatients: impact of disability and interferon beta therapy

  • G. M. Galeazzi
  • S. Ferrari
  • G. Giaroli
  • A. Mackinnon
  • E. Merelli
  • L. Motti
  • M. Rigatelli
ORIGINAL

Abstract

Associations between psychopathology and gender, duration of MS, disability and therapy with beta-interferons were studied in multiple sclerosis (MS) outpatients. A controlled descriptive epidemiological study was carried out in two Italian outpatient MS centres on 50 outpatients with clinically definite relapsing–remitting MS presenting for regular follow-up and 50 healthy controls matched for sex, age and educational level. Subjects were assessed with the Structured Clinical Interview for DSM-IV (SCID I), the Beck Depression Inventory (BDI) and the State Trait Anxiety Inventory (STAI). MS patients reported a higher prevalence of psychiatric disorders (odds ratio 3.17), with 46% (n=23) suffering from major depressive disorder. The risk of suffering from any non-mood psychiatric disorder was also higher in MS patients than in controls (odds ratio 2.67). Risk factors for depression were female sex and severity of disability, but not therapy with interferon beta or longer duration of illness. Disability level, but not therapy with beta-interferons, is a risk factor for depression in MS outpatients. Regular screening for depression in this population is appropriate.

Key words

Multiple sclerosis Psychiatric disorders Depression Disability Interferon beta 

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Copyright information

© Springer-Verlag Italia 2005

Authors and Affiliations

  • G. M. Galeazzi
    • 1
  • S. Ferrari
    • 1
  • G. Giaroli
    • 2
  • A. Mackinnon
    • 3
  • E. Merelli
    • 4
  • L. Motti
    • 5
  • M. Rigatelli
    • 1
  1. 1.Consultation/Liaison Psychiatry Service, Department of Neuroscience TCR, Section of PsychiatryUniversity of Modena and Reggio EmiliaModenaItaly
  2. 2.Department of Medicine and Public Health, Section of PsychiatryUniversity of VeronaVeronaItaly
  3. 3.Centre for Mental Health ResearchAustralian National UniversityCanberraAustralia
  4. 4.Centre for Diagnosis and Therapy of Multiple Sclerosis, Department of Neuroscience TCR, Section of NeurologyModena Policlinico University HospitalModenaItaly
  5. 5.Centre for Diagnosis and Therapy of Multiple Sclerosis, Neurology UnitSanta Maria Nuova HospitalReggio EmiliaItaly

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