Neurological Sciences

, Volume 24, Issue 5, pp 322–328

Epileptic seizures in multiple sclerosis: clinical and EEG correlations

  • P. Striano
  • G. Orefice
  • V. Brescia Morra
  • P. Boccella
  • C. Sarappa
  • R. Lanzillo
  • G. Vacca
  • S. Striano
ORIGINAL

DOI: 10.1007/s10072-003-0183-2

Cite this article as:
Striano, P., Orefice, G., Brescia Morra, V. et al. Neurol Sci (2003) 24: 322. doi:10.1007/s10072-003-0183-2

Abstract.

Epileptic seizures occur more frequently in multiple sclerosis (MS) patients than in the general population. We evaluated clinical, electroencephalographic (EEG) and magnetic resonance imaging (MRI) findings, as well as EEG-MRI correlations and the response to antiepileptic drugs (AEDs) in 270 consecutive patients with definite MS referred to our Department from 1995 to 2002. Thirteen (4.8%) subjects experienced epileptic seizures. In four cases, seizures manifested within 1–2 years (“early-onset”), and in six cases within 8–23 years (“late-onset”) of MS diagnosis. Seizures were usually partial with secondary generalization. Thus, acute symptomatic seizures occurred in three cases. Epilepsy usually appeared late in the course of disease, although a single episode or a cluster of seizures can represent the onset symptom or a relapse of MS. Prognosis of epilepsy during the course of MS is usually good but the choice of AEDs remains a matter of debate.

Key words

Epilepsy Multiple sclerosis EEG Magnetic resonance imaging Status epilepticus Interferon therapy 

Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • P. Striano
    • 1
  • G. Orefice
    • 1
  • V. Brescia Morra
    • 1
  • P. Boccella
    • 1
  • C. Sarappa
    • 1
  • R. Lanzillo
    • 1
  • G. Vacca
    • 1
  • S. Striano
    • 1
  1. 1.Department of Neurological SciencesFederico II University of NaplesNaplesItaly

Personalised recommendations