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Neurological Sciences

, Volume 24, Supplement 5, pp s268–s270 | Cite as

The transition from relapsing-remitting MS to irreversible disability: clinical evaluation

  • M. Trojano
  • D. Paolicelli
  • A. Bellacosa
  • S. Cataldo
Original Paper

Abstract.

The development of a progressive course is by far the most deleterious event in the case of a multiple sclerosis (MS) patient. It occurs in about 90% of relapsing remitting patients by 20–25 years from onset. The clinical transition to secondary progressive MS is phenotypically distinctive and both patients and physicians acknowledge that a fundamental shift in the degree of responsiveness to anti-inflammatory therapies has occurred. This review discusses the clinical studies that provided important findings relating to our understanding on different mechanisms that may contribute to irreversible disability in MS.

Key words

Multiple sclerosis Disease duration Prognosis Age Disability progression 

Copyright information

© Springer-Verlag Italia 2003

Authors and Affiliations

  • M. Trojano
    • 1
  • D. Paolicelli
    • 1
  • A. Bellacosa
    • 1
  • S. Cataldo
    • 1
  1. 1.Department of Neurological and Psychiatric SciencesUniversity of BariBariItaly

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