Evaluation of antifatigue and antioxidant activities of the marine microalgae Isochrysis galbana in mice

  • Wenjie Li
  • Chaodan Luo
  • Yongmei Huang
  • Jingting Zhan
  • Jinli Lei
  • Ning Li
  • Xiaoqi Huang
  • Hui LuoEmail author


The present work aimed to estimate the possible anti-fatigue effect and potential mechanism of Isochrysis galbana (IG) in mice. The anti-fatigue activity of IG (100, 200, and 400 mg/kg) was elucidated by a weight-loaded forced swimming test, and the potential mechanism was explored by determination of fatigue-related biochemical parameters. The results showed that pretreatment with IG significantly extended the exhaustive swimming time and increased the levels of liver glycogen, muscle glycogen and blood glucose in a dose-dependent manner. Besides, the increased levels of alanine aminotransferase, aspartate aminotransferase, blood lactic acid, lactic dehydrogenase, creatine kinase, and blood urea nitrogen by exhausted swimming, were dramatically attenuated by pretreatment with IG. Furthermore, supplementation with IG significantly enhanced the glutathione peroxidase and superoxide dismutase levels, while attenuated the level of malonaldehyde. Taken together, IG possessed appreciable efficacy to alleviate fatigue, and the mechanism might be associated with favorably modulating the process of energy consumption, metabolism, and attenuating oxidative stress injury.


Isochrysis galbana Anti-fatigue activity Antioxidant activity Swimming time Biochemical indicator 



This work was supported by grants from the key lab of Zhanjiang for R&D marine microbial resources in the Beibu Gulf Rim (No. 2012E02), the natural science foundation of Guangdong Province (No. 2015A030310121), and the public service platform of south China Sea for R&D marine biomedicine resources (No. 2017C8A).

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology 2019

Authors and Affiliations

  • Wenjie Li
    • 1
  • Chaodan Luo
    • 2
  • Yongmei Huang
    • 3
  • Jingting Zhan
    • 4
  • Jinli Lei
    • 4
  • Ning Li
    • 1
  • Xiaoqi Huang
    • 2
  • Hui Luo
    • 3
    • 4
    Email author
  1. 1.Department of HematologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangPeople’s Republic of China
  2. 2.Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese MedicineMathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese MedicineGuangzhouPeople’s Republic of China
  3. 3.Marine Biomedical Research Institute, the Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf RimGuangdong Medical UniversityZhanjiangPeople’s Republic of China
  4. 4.Chemistry Teaching and Research Section, the Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf RimGuangdong Medical UniversityZhanjiangPeople’s Republic of China

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