Daily intake of polyamine-rich Saccharomyces cerevisiae S631 prevents osteoclastic activation and bone loss in ovariectomized mice
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An imbalance in the sophisticated regulation between bone-resorbing osteoclasts and bone-forming osteoblasts leads to the pathogenesis and etiology of certain metabolic bone diseases including osteoporosis. Certain polyamines are related to the pathophysiology of some disorders, including Alzheimer’s disease, infectious disease, cancer, and aging. Recently, we demonstrated that oral intake of polyamines (spermidine and spermine) prevented bone loss through preferential disturbance of osteoclastic activation in ovariectomy-induced mouse model of postmenopausal osteoporosis. Here, we showed that daily oral supplementation of a diet containing polyamine-rich Saccharomyces cerevisiae S631 significantly inhibited osteoclastic activation as well as reduction of bone volume in the cancellous bone without affecting uterine weight in ovariectomized mice. Our findings recommend that daily oral supplementation with polyamine-rich yeast diet would be beneficial for prophylaxis of metabolic bone diseases associated with abnormal osteoclast activation.
KeywordsSpermine Spermidine Bone loss Saccharomyces cerevisiae
This work was supported in part by the Japan Society for the Promotion of Science (17KT0051 to E.H.).
Compliance with ethical standards
Conflict of interest
Junichi Node and Shigeru Hiramoto are employees of Nisshin Pharma Inc. All other authors state that they have no conflicts of interest.
- Hunter KJ. A dansyl chloride-HPLC method for the determination of polyamines. Methods Mol. Biol. 79: 119–123 (1998)Google Scholar
- Iezaki T, Fukasawa K, Park G, Horie T, Kanayama T, Ozaki K, Onishi Y, Takahata Y, Nakamura Y, Takarada T, Yoneda Y, Nakamura T, Vacher J, Hinoi, E. Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-kappaB/NFATc1 Pathway. Mol. Cell. Biol. 36: 2451–2463 (2016)CrossRefGoogle Scholar
- Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee. J. Bone Miner. Res. 2: 595–610 (1987)Google Scholar