Postprandial anti-hyperglycemic effect of vitamin B6 (pyridoxine) administration in healthy individuals
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Postprandial blood glucose lowering effect of vitamin B6 (pyridoxine) was evaluated in healthy individuals with normal blood glucose levels. Blood glucose levels were measured every 30 min for 2 h after oral sugar administration with or without 50 mg of pyridoxine. Pyridoxine significantly lowered the postprandial blood glucose levels at 30 min (from 165.95 ± 17.19 to 138.36 ± 20.43, p < 0.01) and 60 min (from 131.40 ± 17.20 to 118.50 ± 15.95) after administration. In addition, the area under the concentration–time curve (AUCt) was reduced by about 8.3% (from 257.08 ± 22.38 to 235.71 ± 12.33, p < 0.05) and the maximum concentration of blood glucose (Cmax) was reduced by about 13.8% (from 165.95 ± 17.19 to 143.07 ± 11.34, p < 0.01) when compared with those of the control group. Our findings suggest that pyridoxine supplementation may be beneficial for controlling postprandial hyperglycemia.
KeywordsPyridoxine Pyridoxine hydrochloride Vitamin B6 Anti-hyperglycemic effects Healthy individuals Postprandial hyperglycemia
This research was financially supported by the Ministry of Trade, Industry, and Energy (MOTIE), Korea, under the “Regional Specialized Industry Development Program” supervised by the Korea Institute for Advancement of Technology (KIAT).
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Conflicts of interest
The authors declare no conflict of interest.
- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 35: S64–S71 (2012)Google Scholar
- Bender DA. The Vitamins. pp. 132–187. In: Introduction to human nutrition. Gibney MJ, Lanham-New SA, Cassidy A, Vorster HH. (ed). John Wiley & Sons, Inc., Hoboken, NJ, USA (2009)Google Scholar
- Centers for Disease Control and Prevention. Diabetes Report Card 2014. Centers for Disease Control and Prevention, US Department of Health and Human Services, Atlanta, GA, USA (2015)Google Scholar