Postprandial anti-hyperglycemic effect of vitamin B6 (pyridoxine) administration in healthy individuals

  • Hyuk Hwa Kim
  • Yu-Ri Kang
  • Hwang-Yong Choi
  • Jung-Yun Lee
  • Jung-Bae Oh
  • Justin S. Kim
  • Young-Cheul Kim
  • Ki Won Lee
  • Young-In Kwon


Postprandial blood glucose lowering effect of vitamin B6 (pyridoxine) was evaluated in healthy individuals with normal blood glucose levels. Blood glucose levels were measured every 30 min for 2 h after oral sugar administration with or without 50 mg of pyridoxine. Pyridoxine significantly lowered the postprandial blood glucose levels at 30 min (from 165.95 ± 17.19 to 138.36 ± 20.43, p < 0.01) and 60 min (from 131.40 ± 17.20 to 118.50 ± 15.95) after administration. In addition, the area under the concentration–time curve (AUCt) was reduced by about 8.3% (from 257.08 ± 22.38 to 235.71 ± 12.33, p < 0.05) and the maximum concentration of blood glucose (Cmax) was reduced by about 13.8% (from 165.95 ± 17.19 to 143.07 ± 11.34, p < 0.01) when compared with those of the control group. Our findings suggest that pyridoxine supplementation may be beneficial for controlling postprandial hyperglycemia.


Pyridoxine Pyridoxine hydrochloride Vitamin B6 Anti-hyperglycemic effects Healthy individuals Postprandial hyperglycemia 



This research was financially supported by the Ministry of Trade, Industry, and Energy (MOTIE), Korea, under the “Regional Specialized Industry Development Program” supervised by the Korea Institute for Advancement of Technology (KIAT).

Compliance with ethical standards

Conflicts of interest

The authors declare no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology 2019

Authors and Affiliations

  1. 1.Department of Agricultural BiotechnologySeoul National UniversitySeoulKorea
  2. 2.Department of Food and NutritionHannam UniversityDaejeonKorea
  3. 3.Institute of KPBKunpoong Bio Co., LtdSeoulKorea
  4. 4.Department of NutritionUniversity of MassachusettsAmherstUSA

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