Food Science and Biotechnology

, Volume 28, Issue 1, pp 181–189 | Cite as

Does Curcuma longa root powder have an effect against CCl4-induced hepatotoxicity in rats: a protective and curative approach

  • Raja Serairi Beji
  • Rim Ben MansourEmail author
  • Iness Bettaieb Rebey
  • Wissem Aidi Wannes
  • Saloua Jameleddine
  • Majdi Hammami
  • Wided Megdiche
  • Riadh Ksouri


This study was conducted to investigate potentially protective and curative effects of Curcuma longa root (turmeric) powder on CCl4-induced hepatotoxicity in rats. Turmeric was administered before (preventive effect) or after (curative effect) treatment with CCl4. Total phenolic and flavonoid levels were 26.35 mg GAE/g and 12.35 mg CE/g, respectively. Using HPLC analysis, turmeric powder was rich in curcumin (62.97%), demethoxycurcumin (20.86%) and bisdemethoxycurcumin (16.17%). Curcuma longa powder showed important in vitro antioxidant activities. Results showed that the activities of aspartate aminotransaminase and alanine aminotransaminase, and the levels of bilirubin and serum lipids were increased in CCl4-treated animals. However, total protein and albumin levels and antioxidant enzyme activities were decreased. Turmeric administration, before or after CCl4 treatment, significantly decreased the activities of marker enzymes and lipid levels in serum. Moreover, total protein and albumin contents were restored to nearly normal levels after turmeric administration accompanied with increase of antioxidant enzymes activities.


Curcuma longa root Liver fibrosis Hepatic enzymes Oxidative stress 



This work was supported by the Tunisian Ministry of Higher Education, Scientific Research and Information and Communication Technologies (LR15CBBC06).

Compliance with ethical standards

Conflict of interest

This research received no grant from any funding agency. Authors declare that there are no conflicts of interest.


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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Raja Serairi Beji
    • 1
    • 2
  • Rim Ben Mansour
    • 2
    Email author
  • Iness Bettaieb Rebey
    • 2
  • Wissem Aidi Wannes
    • 2
  • Saloua Jameleddine
    • 3
  • Majdi Hammami
    • 2
  • Wided Megdiche
    • 2
  • Riadh Ksouri
    • 2
  1. 1.Ecole Supérieure des Sciences et Techniques de la Santé de TunisTunisTunisia
  2. 2.Laboratoire des Plantes Aromatiques et MédicinalesCentre de Biotechnologie de BorjCédria (CBBC)Hammam-LifTunisia
  3. 3.Unité de recherche 03/UR/08-05, Fibrose pulmonaire: Prévention et traitementFaculté de Médecine de TunisTunisTunisia

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