Food Science and Biotechnology

, Volume 27, Issue 5, pp 1429–1438 | Cite as

Physiological and molecular study on the anti-obesity effects of pineapple (Ananas comosus) juice in male Wistar rat

  • Samir A. El-Shazly
  • Mohamed M. Ahmed
  • Mohammad S. AL-Harbi
  • Mohamed E. Alkafafy
  • Hanan B. El-Sawy
  • Sayed A. M. AmerEmail author


The present study was performed to assess anti-obesity effects of raw pineapple juice in high fat diet (HFD)-induced fatness. Based on food type, rats were divided into normal diet and HFD groups. When animals of HFD group become obese, they were given pineapple juice along with either HFD or normal diet. Blood biochemistry, liver and muscle gene expressions were analyzed. HFD induced significant elevations in body weight, body mass index (BMI), body fat accumulation, liver fat deposition and blood lipids while juice restored these parameters near to their normal values. Juice significantly decreased serum insulin and leptin while adiponectin was increased. Juice administration downregulated the increment of FAS and SERBP-1c mRNA expression in liver and upregulated HSL and GLUT-2 expressions. The muscular lipolytic CPT-1 expression was upregulted by juice treatment. Pineapple juice, therefore, may possibly be used as anti-obesity candidate where it decreased lipogenesis and increased lipolysis.


Pineapple juice Rat Obesity Gene expression Histopathology 



We are thankful to Taif University in Kingdom of Saudi Arabia for supporting this work financially (Project No. 1-437-4742).


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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Biotechnology, College of ScienceTaif UniversityTaifSaudi Arabia
  2. 2.Department of Biochemistry, Faculty of Veterinary MedicineKafrelsheikh UniversityKafrelsheikhEgypt
  3. 3.Department of Biochemistry, Faculty of Veterinary MedicineUniversity of Sadat CitySādāt CityEgypt
  4. 4.Department of Biology, College of ScienceTaif UniversityTaifSaudi Arabia
  5. 5.Department of Cytology and Histology, Faculty of Veterinary MedicineUniversity of Sadat CitySādāt CityEgypt
  6. 6.Department of Nutrition and Clinical Nutrition, Faculty of Veterinary MedicineKaferelsheikh UniversityKaferelsheikhEgypt
  7. 7.Department of Forensic Biology, College of Forensic SciencesNaif Arab University for Security SciencesRiyadhSaudi Arabia
  8. 8.Zoology Department, Faculty of ScienceCairo UniversityGizaEgypt

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