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Food Science and Biotechnology

, Volume 27, Issue 5, pp 1525–1530 | Cite as

Analytical method validation for terbutryn using gas chromatography/ion trap, gas chromatography/mass selective detector, and liquid chromatography/triple quadrupole mass spectrometers

  • Hae Won Jang
  • Jangho Lee
  • Hyunwook Choi
  • Tae Gyu Nam
  • Seung-Hyun Kim
  • Kwang-Geun LeeEmail author
Article
  • 131 Downloads

Abstract

Analytical methods including solvent extraction followed by gas chromatography/ion-trap (GC/IT) with scan and MS/MS mode, a GC/mass selective detector (GC/MSD), and liquid chromatography/triple quadrupole mass spectrometers (LC/MS/MS) were optimized to identify and quantify terbutryn. The spike recovery was 96.5% using GC/IT with scan mode and 103.5% with MS/MS mode, 90.3% by GC/MSD, and 92.5% by LC/MS/MS. The limit of detection (LOD) was 0.0015 mg/kg by GC/IT with scan, 0.026 mg/kg with MS/MS mode, 0.015 mg/kg with GC/MSD, and 0.026 mg/kg by LC/MS/MS. Of the four methods, GC/IT with scan mode was determined to be the most sensitive (with LOD: 0.0015 mg/kg and limit of quantitation (LOQ): 0.0047 mg/kg), rapid (retention time: 9.6 min) and the most precise method (relative standard deviation: 17%) for the quantification of terbutryn. GC/IT with scan mode proved to be the more sensitive analytical method for terbutryn than other methods in this study, showing better accuracy and rapid analysis.

Keywords

Terbutryn Gas chromatography/mass selective detector Gas chromatography/ion trap Liquid chromatography/triple quadrupole mass spectrometers 

Notes

Acknowledgements

This research was supported by High Value added Food Technology Development Program (Project Nos. 314078-3 and 316050-03) from Ministry of Agriculture, Food, and Rural Affairs (Republic of Korea).

Compliance with ethical standards

Conflict of interest

The authors declare that there are no conflicts of interest.

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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Hae Won Jang
    • 1
  • Jangho Lee
    • 1
    • 3
  • Hyunwook Choi
    • 1
  • Tae Gyu Nam
    • 1
  • Seung-Hyun Kim
    • 2
  • Kwang-Geun Lee
    • 4
    Email author
  1. 1.Korea Food Research InstituteSeongnamKorea
  2. 2.Department of Applied Bioscience, College of Life and Environmental ScienceKonkuk UniversitySeoulKorea
  3. 3.Food Biotechnology ProgramKorea University of Science and TechnologyDaejeonKorea
  4. 4.Department of Food Science and BiotechnologyDongguk UniversityGoyangKorea

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