Phytochemical and pharmacological screening of Sargassium vulgare from Suez Canal, Egypt
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The current study investigates the phytochemical and pharmaceutical activities of Sargassium vulgare (SVE) collected from the Suez Canal. The prescreening using cytotoxicity was tested against hepatocellular carcinoma cell lines. Furthermore the SVE inhibit cell growth effectively with IC50 = 20.8 µg/ml. The pharmacological studies revealed high antioxidant capacity at all examined concentrations. On the meantime, anticancer assay carried out using tyrosine kinase (PTK) and sphingosine kinase 1 inhibitor screening assays revealed inhibition with 75.73 and 80.01%; respectively. Furthermore, the anti-inflammatory profiling revealed that the activities against COX1, COX2, IL6 and TNF were 77.39, 88.35, 75.38 and 71.24%; respectively. Additionally, the anti-Alzheimer results showed high activity at 1 mg with 76.33%. Finally the antiviral activities using reverse transcriptase inhibition assay give 92.24%. Consequently, it can be easily conclude that the SVE collected from the Suez Canal are excellent source of natural products for nutritional and pharmaceutical applications.
KeywordsSeaweeds Suez Canal Cytotoxic Anti-oxidant Anti-Alzheimer Anti-cancer Anti-inflammatory Anti-viral
I appreciate the effort for all authors to complete this work and their valuable contributions.
- 1.Abdel-Monein, NM, El-Aassar, SA, Shreadah, MA, Nabil-Adam, A. Isolation and identification of Psudomance Sp associated with the marine sponge, Hyrtios aff. Erectus, from the Red sea; Egypt and screening of metabolic pathways NRPs and PKS. Journal of pure & Applied Microbiology. 11(3), 1299–1311, (2017a).Google Scholar
- 2.Abdel-Monein, NM, Shreadah, MA, El-Aassar, SA, Nabil-Adam, A. Protective role of antioxidants capacity of Hyrtios aff. Erectus sponge extract against mixture of persistent organic pollutants (POPs)-induced hepatic toxicity in mice liver: biomarkers and ultrastructural study” Environmental Science and Pollution Research. 1–12, (2017b). DOI https://doi.org/10.10071/s11356-017-9805-8.
- 3.Abdel-Monein, NM, Yacout, GA, Aboul-Ela, HM, Shreadah, MA. Hepatoprotective Activity of Chitosan Nanocarriers Loaded With the Ethyl Acetate Extract of A stenotrophomonas sp. Bacteria Associated with the Red Sea Sponge Amphimedon Ochracea In CCl4 Induced Hepatotoxicity in Rats. Advances in Bioscience and Biotechnology (ABB), 8(1), 27–50, (2017c).Google Scholar
- 4.Shreadah, MA, Abdel-Monein, NM, El-Aassar, SA, Nabil-Adam, A. The Ameliorative Role of a Marine Sponge Extract against Mixture of Persistent Organic Pollutants induced Changes in Hematological Parameters in Mice. Expert Opinion Environmental Biology (EOEB), 6(2), (2017). https://doi.org/10.4172/2325-9655.1000143b
- 5.Elkomy, RG, Ibraheem, IB, Shreadah, MA, Mohammed, R. Optimal Conditions for Antimicrobial Activity Production from Two Microalgae Chlorella marina and Nevicula F. delicatul. Journal of Pure and Applied Microbiology, 9(4): 2725–2732, (2015).Google Scholar
- 6.Elkomy, RG, Ibraheem, IB, Shreadah, MA, Mohammed, R, Ismael, AA. Antibacterial and Antifungal Activity of Three Microalgae Isolated from Egyptian Coast of the Mediterranean Sea”. Journal of Pure and Applied Microbiology, 9(4), 2751–2758, (2015).Google Scholar
- 7.Alghazeer, R, Ibrahim, A, Abdulaziz, A, Abouamer, K (2016). In-vitro antioxidant activity of five selected species of Libyan algae. Int. J. Med. Pharm. Res., 4(1), 1–9, (2016).Google Scholar
- 13.AOAC. Official Methods analysis of association of offcialanaltical chemists 15th End., Association of official analytical chemists.Washington DC., USA. (1990).Google Scholar
- 14.Singh, G, Kumar, P. Extraction, gas chromatography–mass spectrometry analysis and screening of fruits of Terminalia chebula Retz. for its antimicrobial potential, Pharmacognosy Research,5(3): 162–168. https://doi.org/10.4103/0974-8490.112421, (2013).
- 18.Moyo, SJ, Aboud, S, Kasubi, M, Lyamuya, EF, Maselle SY. Antimicrobial resistance among producers and non-producers of extended spectrum beta- lactamases in urinary isolates at a tertiary Hospital in Tanzania, A Short Report. BMC Research Notes, 3:348, (2010). https://doi.org/10.1186/1756-0500-3-348.CrossRefGoogle Scholar
- 24.Mehdinezhad, N, Ghannadi, A, Yegdaneh, A. Phytochemical and biological evaluation of some Sargassum species from Persian Gulf. Research Pharmaceutical Science, 11(3): 243–249, (2016).Google Scholar
- 25.Gauthier S, Leuzy A, Rosa-Neto P. How can we improve transfer of outcomes from randomized clinical trials to clinical practice with disease-modifying drugs in Alzheimer’s disease?, Neurodegener Dis, 13(2-3), 197–199, (2014).Google Scholar
- 27.Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P.and Gerwick, W. H. Marine natural products as anticancer drugs. Molocular Cancer Therapy, 4(2), 333–342, (2005).Google Scholar
- 30.De Almeida, CLF, Falcão, H de S., Lima, GR de M, Montenegro, C de A, Lira, NS, de Athayde-Filho, PF, Batista, LM. Bioactivities from Marine Algae of the Genus Gracilaria. International Journal of Molecular Science, 12(7), 4550–4573, (2011).Google Scholar
- 34.Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutration Review, 68:280–289, (2010) [PubMed]Google Scholar
- 36.Wojdasiewicz, P, Poniatowski, ŁA,Szukiewicz, D. The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis. Mediators of Inflammation. (2014), 561459. http://doi.org/10.1155/2014/561459.