Ameliorative effects of Lycium chinensis on male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic rats
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The root bark of Lycium chinense (LC) has been reported to have potent antioxidant and antidiabetic properties. In the present study, we investigated the attenuative effect of LC against diabetes induced sexual dysfunction and testicular damages in animal models. Diabetic animals were treated with LC (100 and 400 mg/kg) once daily for 6 weeks. At the end of the treatment, mating behavior tests were performed and the animals were sacrificed for the determination of hormonal profile, oxidative stress indices and sperm analysis. LC administration significantly decreased blood glucose level, enhancement of the antioxidant enzyme activities, restored altered sperm characteristics and markedly improved levels of luteinizing hormone, follicle-stimulating hormone and testosterone as compared to the untreated diabetic animals. Furthermore, LC also improved sperm count, viability, motility, increased the reproductive organs weight. The results obtained indicated that L. chinense has beneficial effects in diabetes sexual dysfunction.
KeywordsLycium chinensis Oxidative stress Spermatogenic dysfunction Antioxidant Diabetes mellitus
Thanks to the Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm (No. BM 2014047) and the Public Science and Technology Research Funds Projects of Ocean (No. 201505023) for their grants.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflict of interest.
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