Food Science and Biotechnology

, Volume 26, Issue 6, pp 1763–1772 | Cite as

Modeling the release of antimicrobial agents (thymol and carvacrol) from two different encapsulation materials

  • Pablo A. Ulloa
  • Abel Guarda
  • Ximena Valenzuela
  • Javiera F. Rubilar
  • María J. Galotto


The release of microencapsulated natural antimicrobial (AM) agents (thymol and carvacrol) from two encapsulating matrixes [maltodextrin (MD) and soy protein (SP)] were evaluated for possible use in food packaging coatings. Microcapsules were prepared by oil-in-water (O/W) emulsions at different concentrations (10, 20% for MD and 2, 5% for SP). High encapsulation efficiency ranged from 96 to 99.95% for MD and 93.1 to 100% for SP, with average microcapsule diameters that ranged from 17 to 27.5 and 18.8 to 38 µm, respectively. The release rate with 20% MD-thymol [20MD-T] was faster than with 10% MD-thymol [10MD-T]. Similar results were obtained for carvacrol with the same concentration of MD. Korsmeyer–Peppas and Weibull mathematical models were successfully fitted to the release of the AM agents, describing the Fickian diffusion release of the components. Different release rates were obtained as a function of the chemical nature of the encapsulation material and its concentration.


Release antimicrobial agent Thymol Carvacrol Microencapsulation 



The authors thank the Programa de Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia (Project CEDENNA FB0807). Rubilar gratefully acknowledges the financial support of the Fondecyt-Postdoctoral #3140349 Project and the INNOVA CORFO Project 13IDL1-18281 and DIPEI of the PUC.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Korean Society of Food Science and Technology and Springer Science+Business Media B.V. 2017

Authors and Affiliations

  • Pablo A. Ulloa
    • 1
  • Abel Guarda
    • 2
  • Ximena Valenzuela
    • 2
  • Javiera F. Rubilar
    • 3
  • María J. Galotto
    • 2
  1. 1.Pontificia Universidad Católica de Valparaíso, Escuela de AlimentosValparaisoChile
  2. 2.Food Packaging Laboratory (LABEN-Chile), Food Science and Technology Department, Center for the Development of Nanoscience and Nanotechnology (CEDENNA)Universidad de Santiago de ChileSantiagoChile
  3. 3.Departament of Chemical and Bioprocess EngineeringPontificia Universidad Católica de ChileMacul, SantiagoChile

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