α-glucosidase inhibitory activities of myricetin in animal models of diabetes mellitus
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The α-glucosidase inhibitory activity of myricetin in vivo was investigated. Streptozotocininduced diabetic rats were administered a starch solution (1 g/kg) with and without myricetin (100 mg/kg) or acarbose (40 mg/kg) after an overnight fast. Myricetin and acarbose alleviated postprandial hyperglycemia conditions, compared with untreated rats. Consumption of 0.08% myricetin or 0.03% acarbose in the diet for 7 weeks significantly (p<0.05) reduced the serum fasting glucose, blood glycated hemoglobin, and maltase activities of the small intestine in db/db mice, compared with controls. Myricetin can be beneficial for control of hyperglycemia in diabetes mellitus partly via inhibition of the a-glucosidase activity.
Keywordsmyricetin α-glucosidase glucose glycated hemoglobin db/db mouse
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