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Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages

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Abstract

This study was conducted to compare flavonoids and anti-inflammatory effects in Korean Chrysanthemum species. Leaf samples were identified using HPLC/MS with five flavonoids: luteolin-7-O-rutinoside, luteolin-7-O glucoside, apigenin-7-O-glucoside, apigenin, and acacetin-7-O-rutinoside. Leaf extracts from four taxa dose-dependently suppressed LPS-stimulated NO production significantly (p<0.05) inhibited production of LPS-induced PGE2 compared with controls. The extracts reduced the LPS-induced expressions of inducible NO synthase and cyclooxygenase-2 and inhibited LPS-induced tumor necrosis factor-α and interleukin-6 production for anti-inflammatory effects.

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Authors and Affiliations

  1. Highland Agriculture Research Institute, Rural Development Administration, Pyeongchang, Gangwon, 232-955, Korea

    Su Jeong Kim, Jung Hwan Nam, Su Young Hong & Dong Chil Chang

  2. Department of Pharmaceutical Biochemistry, Kyung Hee University, Seoul, 130-701, Korea

    Kyung-Tae Lee & Hye-Eun Choi

  3. Research Policy Bureau R&D Evaluation Division, Jeonju, Jeonbuk, 560-550, Korea

    Tae Joung Ha

  4. Department of Plant Science, Seoul National University, Seoul, 151-921, Korea

    Ki Sun Kim

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  1. Su Jeong Kim
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  2. Kyung-Tae Lee
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Correspondence to Su Jeong Kim.

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Kim, S.J., Lee, KT., Choi, HE. et al. Anti-inflammatory effects of flavonoids in Korean Chrysanthemum species via suppression of inducible nitric oxide synthase and cyclooxygenase-2 in LPS-induced RAW 264.7 macrophages. Food Sci Biotechnol 24, 975–985 (2015). https://doi.org/10.1007/s10068-015-0125-9

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  • DOI: https://doi.org/10.1007/s10068-015-0125-9

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