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Preventive effect of fermented Gelidium amansii and Cirsium japonicum extract mixture against UVB-induced skin photoaging in hairless mice

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Abstract

Chronic ultraviolet (UV) light causes skin photoaging, characterized by fine and coarse wrinkle formation and dryness. In this study, the effect of fermented Gelidium amansii and Cirsium japonicum extract mixture (FGCM) with lactic acid bacteria on UVB-induced photoaging was evaluated in human dermal fibroblasts and SKH-1 hairless mice. In vitro, FGCM increased type I procollagen levels and suppressed UVB-induced matrix metalloproteinase-1 (MMP-1) expression more effectively than G. amansii and C. japonicum extract mixture (GCM). In vivo, oral administration of FGCM significantly inhibited UVB-induced the number and total depth of wrinkles in the dorsal skin of mice. FGCM suppressed UVB-induced epidermal thickening, and attenuated UVB-induced MMP-13 expression and MMP-2 and MMP-9 activities in dermal tissue. Furthermore, FGCM increased skin hydration and blocked transepidermal water loss in the dorsal skin of mice compared with the UVB-irradiated group. These data indicate that FGCM exerts potent anti-photoaging activities by improving wrinkle formation and dryness.

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Authors and Affiliations

  1. Korea Yakult Co., Ltd., Yongin, Gyeonggi, 446-901, Korea

    Hyun Mee Kim, Dong Eun Lee, Soo Dong Park, Yong Tae Kim, Yu Jin Kim, Ji Woong Jeong, Jung-Hee Lee, Sung Sik Jang & Jae-Hun Sim

  2. School of Biotechnology and Institute of Life Science and Resources, Kyunghee University, Yongin, Gyeonggi, 449-701, Korea

    Hyun Mee Kim & Dae Kyun Chung

  3. Skin Bio Technology Center, Kyunghee University Yongin, Gyeonggi, 449-701, Korea

    Dae Kyun Chung

  4. RNA Inc., College of Life Science, Kyunghee University, Yongin, Gyeonggi, 449-701, Korea

    Dae Kyun Chung

  5. Department of Food and Animal Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul, 151-921, Korea

    Chul-Sung Huh

  6. Research Institute of Eco-friendly Animal Sciences, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang, Gangwon, 232-916, Korea

    Chul-Sung Huh

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  1. Hyun Mee Kim
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Correspondence to Chul-Sung Huh.

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Kim, H.M., Lee, D.E., Park, S.D. et al. Preventive effect of fermented Gelidium amansii and Cirsium japonicum extract mixture against UVB-induced skin photoaging in hairless mice. Food Sci Biotechnol 23, 623–631 (2014). https://doi.org/10.1007/s10068-014-0085-5

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  • DOI: https://doi.org/10.1007/s10068-014-0085-5

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