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Food Science and Biotechnology

, Volume 21, Issue 2, pp 559–564 | Cite as

Effect of oral administration of nutmeg extract on american house dust mite (Dermatophagoides farinae) extract-induced atopic dermatitis-like skin lesions in NC/Nga mice

  • Hee-Chul Chung
  • Myung-Suk Kim
  • Suk-Yeong Mun
  • Bo-Kyung Sa
  • Jae-Yoon Chung
  • Do-Un Kim
  • Jae-Kwan HwangEmail author
Research Article

Abstract

The effects of oral administration of nutmeg extract (NE) on atopic dermatitis (AD) were evaluated using NC/Nga mice treated with American house dust mite (Dermatophagoides farinae) extract. In this mouse model of AD, NE suppressed transepidermal water loss, erythema, and the production of serum immunoglobulin E, interleukin (IL)-4, and interferon-γ by auxillary lymph node cells. In addition, NE reduced epidermal thickening and inflammatory cell infiltration into the skin. In skin lesions, NE suppressed IL-13 and tumor necrosis factor (TNF)-α mRNA expression. In the spleen, NE upregulated T-box transcription factor expressed in T cells and downregulated GATA-binding protein 3, which are involved in T helper cell differentiation. Our findings suggest that NE ameliorates AD and may be a potential nutraceutical candidate for treating AD.

Keywords

nutmeg (Myristica fragrans Houtt) atopic dermatitis Dermatophagoides farinae extract NC/Nga mice 

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Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2012

Authors and Affiliations

  • Hee-Chul Chung
    • 1
    • 3
  • Myung-Suk Kim
    • 2
  • Suk-Yeong Mun
    • 2
  • Bo-Kyung Sa
    • 2
  • Jae-Yoon Chung
    • 3
  • Do-Un Kim
    • 3
  • Jae-Kwan Hwang
    • 1
    • 2
    Email author
  1. 1.Department of Biomaterials Science and EngineeringYonsei UniversitySeoulKorea
  2. 2.Department of Biotechnology, College of Life Science and BiotechnologyYonsei UniversitySeoulKorea
  3. 3.Newtree Co., Ltd.Seongnam, GyeonggiKorea

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