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Effect of Dongchunghacho rice on blood glucose level, lipid profile, and antioxidant metabolism in streptozotocin-induced diabetic rats

  • Jee-Hee Park
  • Nam Sook Park
  • Sang Mong Lee
  • Eunju ParkEmail author
Research Article

Abstract

Abstract The aim of this study was to investigate the effect of dongchunghacho rice [polished rice cultivated with Paecilomyces tenuipes (PT) or Cordyceps militaris (CM)] on blood glucose level, lipid profile, and antioxidant metabolism in streptozotocin (STZ)-induced diabetic rats. Results of the oral glucose tolerance test showed a significant decrease in the area under the curve value of dongchunghacho rice-supplemented groups compared with that of the diabetic control (DC) group. Total plasma cholesterol significantly decreased in dongchunghacho rice-supplemented groups compared with those of the DC groups. Dongchunghacho rice treatment also markedly increased the erythrocyte superoxide dismutase. Fasting blood glucose exhibited a significant negative correlation with total radical trapping antioxidant potential (TRAP) (r= −0.509, p=0.003) and a significant positive correlation with CD levels (r= −0.498, p=0.004). These results suggest that a 13.6% of dongchunghacho rice supplementation to polished rice has hypoglycemic, hypocholesterolemic, and antioxidant potential in STZ-induced diabetic rats.

Keywords

dongchunghacho rice streptozotocin-induced diabetes hypoglycemic effect antioxidant status lipid metabolism 

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Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2011

Authors and Affiliations

  • Jee-Hee Park
    • 1
  • Nam Sook Park
    • 2
  • Sang Mong Lee
    • 2
  • Eunju Park
    • 1
    Email author
  1. 1.Department of Food and NutritionKyungnam UniversityChangwon, GyeongnamKorea
  2. 2.College of Natural Resources and Life SciencePusan National UniversityMiryang, GyeongnamKorea

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