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Food Science and Biotechnology

, Volume 19, Issue 6, pp 1673–1677 | Cite as

Cherry silver berry (Elaeagnus multiflora) extracts exert antiinflammatory effects by inhibiting COX-2 and Akt signals in HT-29 colon cancer cells

  • Mee Sook Lee
  • Yun-Kyoung Lee
  • Ock Jin ParkEmail author
Research Note

Abstract

In this study, the potential of cherry silver berry (Elaeagnus multiflora) as a cancer preventive agent through regulating inflammatory signals including cyclooxygenase-2 (COX-2) and Akt was examined. Cherry silver berry has reported to exert anti-oxidative, anti-inflammatory, and anti-proliferative effects. The extracts from seed and flesh of cherry silver berry were obtained, and analyzed COX-2 and Akt activities in cherry silver berry extract treated HT-29 colon cancer cells. The results showed that the treatment of seed extracts reduced cell viability at the concentrations above 1,600 mg/mL, effectively reduced COX-2 and p-Akt expression. In addition, the anti-inflammatory effects seemed to be related to cancer cell death. Both of seed and flesh extracts inhibited cell growth and induced apoptosis in HT-29 cells. These results suggest that extracts of cherry silver berry may contribute to suppressing cancer growth through its anti-inflammatory and anti-proliferative effects, and natural products used as oriental medicine have the possibility to control tumor cell growth.

Keywords

Akt cyclooxygenase-2 apoptosis colon cancer Elaeagnus multiflora 

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Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2010

Authors and Affiliations

  1. 1.Department of Food and NutritionHannam University Daedeok Valley CampusDaejeonKorea

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