Food Science and Biotechnology

, Volume 19, Issue 6, pp 1573–1578 | Cite as

Inhibitory effects of water extracts of fermented rice bran on allergic response



In this study, the effects of water extracts of fermented rice bran (FRBE) on immediate-type allergic reactions in vitro (RBL-2H3 cell line) and in vivo [ovalbumin (OVA) sensitized mice model] were investigated. FRBE inhibited β-hexosaminidase release from RBL-2H3 cells activated by anti-dinitrophenyl (DNP) IgE while FRBE pretreatment profoundly inhibited the systemic allergic reaction induced by compound 48/80. Moreover, FRBE had a significant inhibitory effect on the mRNA expression of anti-DNP IgE-induced tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-4, IL-6, and IL-10, all of which mediate inflammatory reactions triggered by allergic reaction. To determine the mRNA levels of cytokines in an OVA-sensitized mice model after FRBE treatment, spleen cells were harvested with several concentrations of FRBE. The FRBE-treated group showed decreased levels of TNF-α, IFN-γ, IL-6, and IL-10. These results suggest that FRBE suppressed allergic and inflammatory reactions through inhibition of degranulation, histamine release, and pro-inflammatory cytokine production from mast cells.


water extract of fermented rice bran allergic reaction RBL-2H3 cell β-hexosaminidase pro-inflammatory chemotactic cytokine 


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Copyright information

© The Korean Society of Food Science and Technology and Springer Netherlands 2010

Authors and Affiliations

  • Jiang Ping Fan
    • 1
    • 2
  • Kyoung Min Choi
    • 1
  • Gi Dong Han
    • 1
  1. 1.Department of Food Science and Technology, College of Natural ResourcesYeungnam UniversityGyeongsan, GyeongbukKorea
  2. 2.College of Food Science and TechnologyYunnan Agricultural UniversityKunmingChina

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