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Clinical Rheumatology

, Volume 18, Issue 6, pp 462–467 | Cite as

Clinico-Laboratory Characteristics of Patients with Dermatomyositis Accompanied by Rapidly Progressive Interstitial Lung Disease

  • M. Ito
  • S. Kaise
  • S. Suzuki
  • Y. Kazuta
  • Y. Sato
  • M. Miyata
  • T. Nishimaki
  • N. Nakamura
  • R. Kasukawa
Original Article

Abstract:

The clinico-laboratory features of 16 patients with dermatomyositis (DM) were compared between patients with accompanying rapidly progressive interstitial lung disease (RP-ILD, n= 7) and those with chronic interstitial lung disease (C-ILD, n= 9), and also between deceased (seven RP-ILD and three C-ILD) and living patients (six C-ILD). The extent of muscle weakness of the extremities and frequency of autoantibody positivity were significantly lower in DM patients with RP-ILD than in DM patients with C-ILD. Furthermore, significantly lower serum ceatine kinase/lactate dehydrogenase levels (0.26 ± 0.27) were found in the 10 patients who died than in the six living patients (1.21 ± 1.09). A higher CD4+/CD8+ T-lymphocyte ratio in the peripheral blood (3.51 ± 2.65) was detected in the four DM patients with RP-ILD who died than in the six living DM patients with C-ILD (1.22 ± 0.49).

Key words:Autoantibodies – CD4+/CD8+ ratio – CK/LDH ratio – Dermatomyositis – Muscle weakness – Rapidly progressive interstitial lung disease 

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Copyright information

© Clinical Rheumatology 1999

Authors and Affiliations

  • M. Ito
    • 1
  • S. Kaise
    • 1
  • S. Suzuki
    • 1
  • Y. Kazuta
    • 1
  • Y. Sato
    • 1
  • M. Miyata
    • 1
  • T. Nishimaki
    • 1
  • N. Nakamura
    • 2
  • R. Kasukawa
    • 1
  1. 1.Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima, JapanJP
  2. 2.Department of Pathology I, Fukushima Medical University School of Medicine, Fukushima, JapanJP

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