Clinical Rheumatology

, Volume 39, Issue 1, pp 159–166 | Cite as

Rheumatoid arthritis and neurodegenerative dementia: a nested case-control study and a follow-up study using a national sample cohort

  • Chanyang Min
  • Woo Jin Bang
  • Miyoung Kim
  • Dong Jun Oh
  • Hyo Geun ChoiEmail author
Original Article



The present study evaluated the associations between rheumatoid arthritis (RA) and neurodegenerative dementia using a Korean national sample cohort.


We designed two studies using the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Study I included participants with dementia matched 1:4 with controls and analyzed the participants’ history of RA. Study II included participants with RA matched 1:4 with controls and analyzed the occurrence of dementia. RA was defined by the presence of relevant ICD-10 codes (M05 or M06) and medication histories. Neurodegenerative dementia was defined using ICD-10 codes (G30 or F00). Crude and adjusted odds ratios (ORs) were analyzed using conditional logistic regression analyses. Crude and adjusted hazard ratios (HRs) were analyzed using the stratified Cox proportional hazard model. Subgroup analyses were performed on groups stratified by age and sex.


The adjusted ORs for RA were 0.96 (95% CI = 0.78–1.16, P = 0.644) in the dementia group in study I. The adjusted HRs for dementia were 0.91 (95% CI = 0.76–1.10, P = 0.319) in the RA group in study II. No subgroup analysis reached the statistical significance level.


We could not identify any significant relationship between RA and dementia.

Key Points

Two studies were conducted to identify the relationship between rheumatoid arthritis and dementia using national cohort data.

Neither study showed any association between rheumatoid arthritis and dementia.


Cohort study Dementia Inflammation Korean population Rheumatoid arthritis 



The manuscript was edited for English language, grammar, punctuation, spelling, and overall style by the highly qualified native English-speaking editors at American Journal Experts (6619-3130-000E-B743-046P).

Funding information

This work was supported in part by a research grant (NRF-2018-R1D1A1A02085328) from the National Research Foundation (NRF) of Korea and Hallym Research Fund (HURF-2018-53).

Compliance with ethical standards

The ethics committee of Hallym University (2014-I148) approved the use of the data. The need for written informed consent was waived by the Institutional Review Board.



Supplementary material

10067_2019_4769_MOESM1_ESM.pdf (183 kb)
ESM 1 (PDF 182 kb)


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  1. 1.Hallym Data Science LaboratoryHallym University College of MedicineAnyangSouth Korea
  2. 2.Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart HospitalHallym University College of MedicineAnyang-siRepublic of Korea
  3. 3.Graduate School of Public HealthSeoul National UniversitySeoulSouth Korea
  4. 4.Department of UrologyHallym University Sacred Heart HospitalAnyangSouth Korea
  5. 5.Department of Laboratory MedicineHallym University College of MedicineAnyangSouth Korea
  6. 6.Department of Internal Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea

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