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Clinical Rheumatology

, Volume 38, Issue 12, pp 3609–3617 | Cite as

Associations between serum IL-8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis

  • Guangfeng Ruan
  • Jianhua Xu
  • Kang Wang
  • Shuang Zheng
  • Juan Wu
  • Fuqin Bian
  • Bingru Chang
  • Yan Zhang
  • Tao Meng
  • Zhaohua Zhu
  • Weiyu Han
  • Changhai DingEmail author
Original Article
  • 169 Downloads

Abstract

Objective

The aim of this study was to investigate cross-sectional associations between serum levels of IL-8 and the above outcomes in patients with knee osteoarthritis (OA).

Methods

A total of 160 subjects with clinical knee OA were included. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and Lequesne index were used to assess the joint symptom. Magnetic resonance imaging was used to measure knee structural abnormalities including infrapatellar fat pad (IPFP) signal intensity alternation. Knee radiographic OA was assessed by radiography using the Kellgren-Lawrence (K-L) grading system. Enzyme-linked immunosorbent assay was used to measure the serum levels of IL-8 and cartilage or bone biomarkers.

Results

In multivariable analyses, serum IL-8 was positively associated with WOMAC weight-bearing pain (β 2.85, P = 0.028), WOMAC physical dysfunction (β 12.71, P = 0.048), and Lequesne index (β 1.65, P = 0.015), and had positive associations with IPFP signal intensity alteration (OR 3.18, P = 0.011) and serum levels of N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), matrix metalloproteinase (MMP)3, and MMP13 (β 0.24–1.44, all P < 0.05) in patients with clinical knee OA. Furthermore, there were positive associations between IL-8 and WOMAC score (β 22.49, P = 0.037), K-L grades (OR 3.88, P = 0.013), and IPFP signal intensity alteration (OR 3.20, P = 0.033) in patients with radiographic OA.

Conclusions

Serum levels of IL-8 were positively associated with increased knee symptoms, IPFP signal intensity alteration, and serum levels of bone and/or cartilage biomarkers, suggesting that IL-8 may have a role to play in knee OA.

Key Point

This study systemically investigates the associations between serum IL 8 and knee symptoms, joint structures, and cartilage or bone biomarkers in patients with knee osteoarthritis, and some significant associations have been found, suggesting that IL 8 may have a role to play in knee OA.

Keywords

IL-8 Magnetic resonance imaging Osteoarthritis 

Notes

Acknowledgments

We appreciate the support of the Department of Rheumatology and Immunology at the First Affiliated Hospital of Anhui Medical University and, of course, all the participants.

Funding information

This study has been supported by the National Natural Science Foundation of China (81172865).

Compliance with ethical standards

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Guangfeng Ruan
    • 1
    • 2
    • 3
  • Jianhua Xu
    • 1
  • Kang Wang
    • 1
  • Shuang Zheng
    • 1
    • 2
  • Juan Wu
    • 1
  • Fuqin Bian
    • 1
  • Bingru Chang
    • 1
  • Yan Zhang
    • 2
    • 3
  • Tao Meng
    • 2
  • Zhaohua Zhu
    • 2
    • 3
  • Weiyu Han
    • 2
    • 3
  • Changhai Ding
    • 1
    • 2
    • 3
    Email author
  1. 1.Department of Rheumatology and Immunology, Arthritis Research Institutethe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Menzies Institute for Medical ResearchUniversity of TasmaniaHobartAustralia
  3. 3.Clinical Research CentreZhujiang Hospital, Southern Medical UniversityGuangzhouChina

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