Clinical Rheumatology

, Volume 38, Issue 11, pp 3139–3143 | Cite as

The comparison of visfatin levels of gingival crevicular fluid in systemic lupus erythematosus and chronic periodontitis patients with healthy subjects

  • Maryam Rezaei
  • Mojtaba BayaniEmail author
  • Baharak Tasorian
  • Soroush Mahdian
Original Article



Visfatin is an adipokine and has a crucial role in pro-inflammatory response. The aim of this study was investigating the visfatin levels of gingival crevicular fluid (GCF) in patients with systemic lupus erythematosus (SLE) and chronic periodontitis and healthy subjects.

Materials and methods

Sixty non-obese females were selected based on their clinical parameters into four groups: 15 healthy subjects (H-H), 15 systemically healthy individuals with chronic periodontitis (H-CP), 15 SLE patient with CP (SLE-CP), and 15 SLE patients without CP (SLE-H). GCF samples were collected to estimate the levels of visfatin using enzyme-linked immunosorbent assay (ELISA).


Investigating the amount of visfatin in the GCF showed that there is a significant difference between visfatin amount of GCF in SLE patients and chronic periodontitis (L-CP) in comparison with other groups (P < 0.001).


Visfatin levels have correlated positively with all the clinical periodontal parameters and its levels in (L-CP) group are highest in comparative with other groups. This finding suggests visfatin has a possible role in association between these two inflammatory conditions.

Key Point

Visfatin in systemic lupus erythematosus


Chronic periodontitis Gingival crevicular fluid Systemic lupus erythematosus Visfatin 



This study was a part of the dentistry thesis that was funded by Arak University of Medical Sciences.

Compliance with ethical standards

Written informed consent was obtained from those who agreed to participate voluntarily. The protocol of the study was approved by the Ethics Committee of Arak University of Medical Sciences (No. IR.ARAKMU.REC.1397.31).




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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  1. 1.Student Research Committee, School of DentistryArak University of Medical SciencesArakIran
  2. 2.Department of Periodontics, School of DentistryArak University of Medical ScienceArakIran
  3. 3.Department of Rheumatology, School of MedicineArak University of Medical ScienceArakIran

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