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Clinical Rheumatology

, Volume 39, Issue 1, pp 177–187 | Cite as

SAPHO: has the time come for tailored therapy?

  • Adelaide Sofia Batalha FigueiredoEmail author
  • Ana Luísa Oliveira
  • António Caetano
  • Maria Francisca Moraes-Fontes
Case Based Review
  • 229 Downloads

Abstract

SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome is a heterogeneous condition combining osteoarticular and cutaneous manifestations. Conventional treatments are mostly ineffective. We hereby report two patients, the first with an aggressive form of disease and the second with an incomplete response to two different anti-TNF-α agents. Both were successfully treated with tocilizumab and ustekinumab, respectively, over a long period of time. A narrative review of a biological therapy in SAPHO syndrome yielded very little information on the specific use of these agents. We highlight the advantages of personalising therapy and describe emerging promising treatments for this disease.

Keywords

Anti-IL-1 agents Anti-IL-12/IL-23 agents Anti-IL-6 agents Anti-TNF-α agents SAPHO syndrome Treatment 

Notes

Compliance with ethical standards

Disclosures

None.

Consent

Both patients gave informed consent for the publication of their case report and related images.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  1. 1.Unidade de Doenças Auto-imunes/Serviço Medicina 7.2, Hospital de Curry CabralCentro Hospitalar Universitário de Lisboa CentralLisbonPortugal
  2. 2.Serviço de Medicina IVHospital de Santarém EPESantarémPortugal
  3. 3.Serviço de Medicina I, Unidade Local de Saúde do Baixo AlentejoHospital José Joaquim FernandesBejaPortugal
  4. 4.Serviço de Radiologia do Hospital de Curry CabralCentro Hospitalar Universitário de Lisboa CentralLisbonPortugal

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