Risk of pancreatic cancer in patients with systemic lupus erythematosus: a meta-analysis
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Accumulating evidences suggest that the incidence of several cancers is higher in systemic lupus erythematosus (SLE) than in general population. However, the finding on pancreatic cancer risk is inconsistent. This meta-analysis aimed to determine whether SLE patients are at risk for pancreatic cancer.
We searched PubMed, Embase, and the Cochrane database to screen the studies meeting our criteria. The hazard ratios (HRs) and its 95% confidence interval (CIs) were calculated from a meta-analysis.
Eleven cohort studies were included in the final analysis. Overall, patients with SLE had an increased risk of pancreatic cancer (HR = 1.42, CI = 1.32–1.53). In subgroup analysis, hospital-based (HR = 1.43, CI = 1.32–1.54), retrospective (HR = 1.42, CI = 1.32–1.54), over 10 years followed (HR = 1.44, CI = 1.33–1.55), and low-quality studies (HR = 1.42, CI = 1.31–1.53) remained robust. Significant publication bias was not observed among the studies (p = 0.533).
• Cancer incidence in SLE patients is increasing, but the data concerning pancreatic cancer remains inconclusive.
• Our meta-analysis indicated that the risk of pancreatic cancer was significantly increased in SLE patients.
• A well-designed, long-period followed study is needed to confirm the association.
KeywordsAssociation Meta-analysis Pancreatic cancer Systemic lupus erythematosus
Seo, Yeo, and Hwang designed the study and wrote and edited the manuscript.
All four authors searched literature and extracted the data.
Hwang coordinated the study.
All four authors interpreted and discussed the results, revised manuscript, and approved the final version.
Compliance with ethical standards
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