Clinical Rheumatology

, Volume 38, Issue 11, pp 3099–3107 | Cite as

The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus

  • Yan Du
  • Fengyin Sun
  • Meiju Zhou
  • Xinyu Wu
  • Wenjia Sun
  • Yujie Jiang
  • Qi Cheng
  • Xiaochan Chen
  • Huaxiang WuEmail author
  • Jing XueEmail author
Original Article



Our previous study has shown that functional leukocyte immunoglobulin-like receptors A3 (LILRA3) contributes to susceptibility and subphenotypes of systemic lupus erythematosus (SLE). However, the mechanism remains unclear. We aimed to evaluate the role of LILRA3 in SLE.


One hundred twenty-six SLE patients and 48 healthy controls were recruited in this study. Functional studies were performed using intracellular flow cytometry and ELISA.


Both LILRA3 levels in serum and CD14+ monocytes were significantly elevated in SLE patients compared with healthy controls. Elevated LILRA3 level was found positively correlated with SLEDAI. Furthermore, more elevated LILRA3 levels were found in patients with higher SLEDAI, presence of lupus nephritis, and thrombocytopenia.


Both LILRA3 levels in serum and CD14+ monocytes significantly increased in SLE and positively correlated with disease activity and severity. The upregulation of LILRA3 expression may serve as a biomarker of disease activity and severity of SLE.

Key Points

LILRA3 contributes to susceptibility and subphenotypes of SLE; LILRA3 is elevated in SLE patients.

Increased LILRA3 correlated with disease activity and severity.

LILRA3 may serve as a biomarker of disease activity and severity of SLE.


CD14+ monocytes LILRA3 Systemic lupus erythematosus 


Author contributions

Study conception and design: Du, Xue, Huaxiang Wu.

Acquisition of data: Du, Fengyin Sun, Xinyu Wu, Zhou, Jiang, Cheng, Xue, Wenjia Sun, Chen, Huaxiang Wu.

Analysis and interpretation of data: Du, Fengyin Sun, Xue, Huaxiang Wu.

Manuscript preparation: Du, Xue, Huaxiang Wu.

Statistical analysis: Du, Fengyin Sun, Huaxiang Wu.


Supported by the National Natural Science Foundation of China (No. 81501388), Zhejiang Provincial Public Technology Applied Research Project (No. 2015C33177, No. 2017C33032, No. LGF19H100003) and Zhejiang Provincial Medical Science and Technology Plan Project (No. 2017KY381).

Compliance with ethical standards



Supplementary material

10067_2019_4624_MOESM1_ESM.docx (21 kb)
ESM 1 (DOCX 21 kb)


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Yan Du
    • 1
  • Fengyin Sun
    • 2
  • Meiju Zhou
    • 1
  • Xinyu Wu
    • 1
  • Wenjia Sun
    • 1
  • Yujie Jiang
    • 1
  • Qi Cheng
    • 1
  • Xiaochan Chen
    • 1
  • Huaxiang Wu
    • 1
    Email author
  • Jing Xue
    • 1
    Email author
  1. 1.Department of RheumatologyThe Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina
  2. 2.Department of Pediatric Surgery, Qilu HospitalShandong UniversityJinanChina

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