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Comparison of clinical presentation and incidence of cardiopulmonary complications between male and female Thai patients with early systemic sclerosis: inception cohort study

  • Suparaporn WangkaewEmail author
  • Surachet Tungteerabunditkul
  • Narawudt Prasertwittayakij
  • Juntima Euathrongchit
Original Article
  • 33 Downloads

Abstract

Objectives

To determine the prevalence of clinical manifestations and incidence rate of cardiopulmonary complications in a comparison between men and women with early SSc.

Methods

An inception cohort of early-SSc patients at the Rheumatology Clinic, Maharaj Nakorn Chiang Mai Hospital, between January 2010 and June 2016, was used. All patients were assessed for clinical manifestations and underwent ECG, echocardiography, and HRCT at the study entry and then annually.

Results

One hundred and fifteen patients (46 male, 90 dcSSc) with a mean (SD) disease duration of 11.6 months (8.8) at cohort entry were enrolled during a mean (SD) observational period of 3.8 years (1.6). At enrollment, the male group had a higher prevalence of dcSSc subtype (91.3% vs. 69.5%, p = 0.006), hypo-hyperpigmentation (84.8% vs. 65.2%, p = 0.021), myositis (26.1% vs. 10.1%, p = 0.024), and right ventricular dysfunction [RVD] (8.7% vs. 0%, p = 0.024) compared with women. At the last visit, the male group had a higher cumulative prevalence of digital ulcers (47.8% vs. 27.5%, p = 0.026), telangiectasia (93.5% vs. 69.6%, p = 0.002), joint contracture (69.6% vs. 43.5%, p = 0.006), tendon friction rub (39.1% vs. 20.3%, p = 0.027), LVEF < 50% (21.7% vs. 8.7%, p = 0.048), and RVD (34.8% vs. 7.2%, p < 0.001). The male group had a significantly higher incidence rate of RVD (8.21 vs. 1.99 per 100 person-years, p = 0.006) and interstitial lung disease [ILD] (65.25 vs. 40.36 per 100 person-years, p = 0.022) compared to women.

Conclusions

In this study cohort, it was found that men with SSc had more severe clinical manifestations and higher incidence rate of RVD and ILD compared to women. Increased awareness of cardiopulmonary complications in men even in early phase of SSc is crucial.

Key Points

Male patients with SSc have more severe disease manifestations compared to women.

Even in the early phase of the disease, men were found to have higher incidence rates of right ventricular dysfunction and interstitial lung disease than women.

Increased awareness regarding cardiopulmonary complications in men with early SSc is crucial for effective management of these complications.

Keywords

Gender Incidence Men Systemic sclerosis Women 

Notes

Acknowledgments

The authors thank Mrs. Antika Wongthanee, medical statistician, for her statistical analysis.

Compliance with ethical standards

This study was approved by the Chiang Mai University Research Ethics Committee in compliance with the 1964 Declaration of Helsinki and its later amendment. All patients signed a written consent form at study entry.

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2019

Authors and Affiliations

  • Suparaporn Wangkaew
    • 1
    Email author
  • Surachet Tungteerabunditkul
    • 1
  • Narawudt Prasertwittayakij
    • 2
  • Juntima Euathrongchit
    • 3
  1. 1.Divisions of Rheumatology, Department of Internal Medicine, Faculty of MedicineChiang Mai UniversityChiang MaiThailand
  2. 2.Division of Cardiology, Faculty of MedicineChiang Mai UniversityChiang MaiThailand
  3. 3.Division of Diagnostic Radiology, Faculty of MedicineChiang Mai UniversityChiang MaiThailand

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