Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review
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Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. It has been reported to accompany certain infections such as hepatitis B, hepatitis C, infectious mononucleosis, and coxsackie group A. However, it has never been reported to be linked to histoplasmosis in the literature. To the best of our knowledge, we report the first case of HUVS presenting concurrently with pulmonary histoplasmosis.
KeywordsHistoplasmosis Hypocomplementemia Pulmonary Urticaria Vasculitis
The author would like to thank the people who were involved in the patient’s care but not in writing.
Mohammad Alomari: Contributed to project design, writing, editing, and critical revision of the manuscript and has read and approved the manuscript.
Laith Al Momani: Contributed by drafting the manuscript, performed literature search, reviewed, and has read and approved the manuscript.
Shrouq Khazaaleh: Contributed to project design, writing, editing, and critical revision of the manuscript and has read and approved the manuscript.
Shaden Al Momani: Contributed to project design, writing, editing, and critical revision of the manuscript and has read and approved the manuscript.
Kinanah Yaseen: Contributed to project design, writing, editing, and critical revision of the manuscript and has read and approved the manuscript.
Bassam Alhaddad: Contributed to project design, writing, editing, and critical revision of the manuscript and has read and approved the manuscript.
Compliance with ethical standards
Our institutions do not require ethical approval for reporting individual cases or case series.
Verbal informed consent was obtained from the patient for his anonymized information to be published in this article.
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