Shedding light on vasculitis in Egypt: a multicenter retrospective cohort study of characteristics, management, and outcome
- 60 Downloads
The frequency of different vasculitides and their characteristics vary among different regions. The identification of geographic disparities of disease phenotypes helps the development of international criteria, allowing the classification of patients of different ethnicities. This study aimed to describe the frequency, characteristics, course, response to treatment, and outcome of the different adulthood vasculitides in Egypt.
This was a multicenter study in which the medical records of adult Egyptian patients diagnosed with vasculitis between 2002 and 2018 were retrospectively reviewed.
The most frequent vasculitides in Egypt were Behçet’s disease (76%), hepatitis C virus vasculitis (13.9%), and granulomatosis with polyangiitis (3.9%). Most patients (73.8%) had a major event at the time of diagnosis. Generalized granulomatosis with polyangiitis was more common than the localized type (90% versus 10%, respectively). The aortic arch and its branches were the most common affected sites of Takayasu arteritis. Of vasculitides, Behçet’s disease and giant cell arteritis were associated with the greatest rates of relapse (62.7% and 33.3%, respectively). Delayed diagnosis and permanent organ damage were reported in 69.9% and 68.9% of patients, respectively. A low mortality rate was noted (1.3%).
The most common types of adulthood vasculitides in Egypt are Behçet’s disease, hepatitis C virus vasculitis, and granulomatosis with polyangiitis. Major organ involvement is frequent. Delayed diagnosis and permanent organ damage are common.
KeywordsEgypt Epidemiology Geography Vasculitides Vasculitis
The authors would like to thank Prof Dr. Geilan Mahmoud Abd El-Moniem, Professor of Rheumatology and Clinical Immunology, Cairo University, for reviewing the work and providing valuable advice.
Compliance with ethical standards
- 3.Watts RA (2005) Epidemiology of vasculitis in India-what is known? J Indian Rheumatol Assoc 13:8–15Google Scholar
- 4.Leonardo NM, McNeil J (2015) Behçet’s disease: is there geographical variation? a review far from the Silk Road. Int J Rheumatol 2015:945262. https://doi.org/10.1155/2015/945262
- 8.Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY (1990) The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum 33(8):1094–1100CrossRefGoogle Scholar
- 10.International Team for the Revision of International Criteria for Behçet’s Disease (2008) Clinical manifestations of Behçet’s disease. The ITR-ICBD report. Clin Exp Rheumatol 26(Suppl 50):S1–S18Google Scholar
- 14.Khalifa M, Karmani M, Jaafoura NG, Kaabia N, Letaief AO, Bahri F; Study Group of GCA in Tunisia (2009) Epidemiological and clinical features of giant cell arteritis in Tunisia. Eur J Intern Med 20:208–212Google Scholar
- 16.Hatemi G, Seyahi E, Fresko I, Talarico R, Hamuryudan V (2015) Behçet's syndrome: a critical digest of the 2014–2015 literature. Clin Exp Rheumatol 33:S3–S14Google Scholar
- 19.Joshi VR, Mittal G (2006) Vasculitis—Indian perspective. J Assoc Physicians India 54(Suppl):12–14Google Scholar
- 30.Gamarra AI, Coral P, Quintana G, Toro CE, Flores LF, Matteson EL et al (2010) History of primary vasculitis in Latin America. Med Sci Monit 16(3):RA58–RA72Google Scholar
- 31.Furuta S, Chaudhry AN, Hamano Y, Fujimoto S, Nagafuchi H, Makino H, Matsuo S, Ozaki S, Endo T, Muso E, Ito C, Kusano E, Yamagata M, Ikeda K, Kashiwakuma D, Iwamoto I, Westman K, Jayne D (2014) Comparison of phenotype and outcome in microscopic polyangiitis between Europe and Japan. J Rheumatol 41:325–333CrossRefGoogle Scholar
- 32.Handa R, Wali JP, Biswas A, Aggarwal P, Wig N (1997) Wegener’s granulomatosis- a clinicopathologic study. J Assoc Physicians India 45:536–539Google Scholar
- 44.Handa R, Wali JP, Gupta SD, Dinda AK, Aggarwal P, Wig N, Biswas A (2001) Classic polyarteritis nodosa and microscopic polyangiitis-a clinicopathologic study. J Assoc Physicians India 49:314–319Google Scholar
- 45.Attia TH, Morsy SM, Hassan BA, Ali ASA (2018) Kawasaki disease among Egyptian children: a case series. Glob Cardiol Sci Pract 2017, 25. https://doi.org/10.21542/gcsp.2017.25