Clinical Rheumatology

, Volume 38, Issue 2, pp 495–502 | Cite as

Serum interleukin-37 level and interleukin-37 gene polymorphism in patients with Behçet disease

  • Selcan ÖzgüçlüEmail author
  • Türker Duman
  • Funda Seher Özalp Ateş
  • Orhan Küçükşahin
  • Sevgi Çolak
  • Ümit Ölmez
Original Article


Behçet’s disease (BD) is a chronic inflammatory disease. The etiopathogenesis of BD is not well understood and several cytokines and genetic factors have been investigated. Interleukin (IL)-37, which a member of IL-1 family is an anti-inflammatory cytokine. The aim of the study was to analyze serum IL-37 level and IL-37 gene polymorphisms to assess its possible role in BD. Two hundred twenty-three patients with BD and 80 healthy controls (HC) were enrolled. Serum IL-37 level was measured using an enzyme-linked immunosorbent assay (ELISA). Deoksiribo Nucleic acids (DNA) were extracted using a genomic DNA isolation kit. Single nucleotide polymorphism (SNP) of IL-37 gene (rs3811047) was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP) methods. Serum IL-37 level was not significantly different in BD and HC (p > 0.05). Serum IL-37 level was not associated with the disease activity (p > 0.05). However, its level was higher in mucocutaneous involvement compared with systemic involvement (p = 0.002) and HC (p = 0.005). IL-37 gene polymorphisms were similar in BD and HC (p > 0.05). IL-37 may play a role in the etiopathogenesis of BD by contributing to manifestation with more moderate clinical symptoms.


Behçet’s disease Cytokine Gene polymorphism Interleukin-37 


Funding information

This study received financial assistance from the Ankara University Scientific Research Project Coordination Unit.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  • Selcan Özgüçlü
    • 1
    Email author
  • Türker Duman
    • 2
  • Funda Seher Özalp Ateş
    • 3
  • Orhan Küçükşahin
    • 4
  • Sevgi Çolak
    • 5
  • Ümit Ölmez
    • 5
  1. 1.Immunology and AllergyAnkara Dışkapı Yıldırım Beyazıt Education and Research HospitalAnkaraTurkey
  2. 2.Faculty of Science, BiologyAnkara UniversityAnkaraTurkey
  3. 3.BiostatisticsAnkara University School of MedicineAnkaraTurkey
  4. 4.RheumatologyAnkara Liv HospitalAnkaraTurkey
  5. 5.Immunology and AllergyAnkara University School of MedicineAnkaraTurkey

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