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Clinical Rheumatology

, Volume 38, Issue 2, pp 431–436 | Cite as

Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population

  • Si Chen
  • Xiaoting Wen
  • Qian Wang
  • Jing Li
  • Yuan Li
  • Liubing Li
  • Hui Yuan
  • Fengchun Zhang
  • Yongzhe LiEmail author
Original Article
  • 56 Downloads

Abstract

The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in the BANK1 gene and polymyositis/dermatomyositis (PM/DM) in a Chinese Han population. In total, 363 PM patients, 654 DM patients, and 1280 healthy controls were recruited and genotyped using the Sequenom MassArray system. A significant allele association was observed in rs3733197 among the PM/DM patients (OR 0.81, 95%CI 0.70–0.94, Pc = 1.83 × 10−2). Notably, rs3733197 was associated with DM and PM/DM patients with ILD involvement (Pc = 0.026; Pc = 6.0 × 10−3, respectively). However, no statistically significant difference was observed in the allele or genotype frequencies of three SNPs (rs4522865, rs17266594, and rs10516487) among the DM, PM, and PM/DM patients and healthy controls (all Pc > 0.05). This study was the first to demonstrate that a BANK1 gene SNP (rs3733197) could confer genetic predisposition in PM/DM patients and PM/DM patients with ILD in a Chinese Han population.

Keywords

Association BANK1 Dermatomyositis Polymyositis rs3733197 

Notes

Acknowledgements

We thank all IIM patients and healthy controls involved in the study.

Funding

This work was supported by funding from the National Natural Science Foundation of China Grants 81373188, the National Science Technology Pillar Program in the 12th 5-year Plan (2014BAI07B00), and the Capital Health Research and Development of Special (2014-1-4011).

Compliance with ethical standards

This study was approved by the Ethics Committee of the Peking Union Medical College Hospital (Beijing, China). Informed consent was obtained from all individuals participating in this study.

Disclosures

None.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  • Si Chen
    • 1
    • 2
  • Xiaoting Wen
    • 1
  • Qian Wang
    • 1
  • Jing Li
    • 1
  • Yuan Li
    • 1
  • Liubing Li
    • 1
  • Hui Yuan
    • 2
  • Fengchun Zhang
    • 1
  • Yongzhe Li
    • 1
    • 3
    Email author
  1. 1.Department of Rheumatology and Clinical Immunology, Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of EducationBeijingChina
  2. 2.Department of Clinical Laboratory, Beijing Anzhen HospitalCapital Medical UniversityBeijingChina
  3. 3.Department of Rheumatology and Clinical ImmunologyPeking Union Medical College and Chinese Academy of Medical SciencesBeijingChina

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