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Clinical Rheumatology

, Volume 37, Issue 8, pp 2161–2168 | Cite as

Prevalence and factors associated with disturbed sleep in outpatients with ankylosing spondylitis

  • Anliu Nie
  • Chen Wang
  • Yuqing Song
  • Xia Xie
  • Hui Yang
  • Hong Chen
Original Article
  • 139 Downloads

Abstract

Sleep disturbance is prevalent among patients with ankylosing spondylitis (AS) and is considered a multifactorial issue. The study was designed to investigate sleep disturbance and its associated factors in AS outpatients in Southwest China. Patients were recruited by convenience sampling in this cross-sectional study. The Pittsburgh Sleep Quality Index (PSQI), the Bath AS Disease Activity Index (BASDAI), the Bath AS Functional Index (BASFI), the Bath AS Patient Global Score (BAS-G), and the Hospital Anxiety and Depression Scale (HADS) were used to assess sleep quality, disease activity, function status, global well-being, depression, and anxiety. Spearman’s correlation, t test, ANOVA, and multiple linear regression analysis were used to explore the associated factors of sleep disturbance. Of the 281 outpatients included in the study, 190 (67.6%) patients had sleep disturbance. The married patients, the patients with extra-spinal manifestation, depression and anxiety, longer duration of diagnostic delay, higher disease activity, worse functional status and global well-being, high level of pain, and fatigue, had poorer sleep quality (P < 0.05). Multiple linear regression analysis revealed age (β = 0.087, P = 0.102), BAS-G (β = 0.181, P = 0.003), fatigue (β = 0.170, P = 0.002), anxiety (β = 0.151, P = 0.002) and nocturnal back pain (β = 0.192, P = 0.001), extra-spinal manifestation (β = 0.120, P = 0.012), and duration of diagnostic delay (β = 0.174, P = 0.001) were the contributors to PSQI. Sleep disturbance is common in AS patients in Southwest China. It may be useful to keep regular exercise, strengthen the management of pain, relieve anxiety, and prevent and treat extra-spinal manifestation for improving sleep quality.

Keywords

Ankylosing spondylitis China Sleep disturbance Sleep quality 

Notes

Acknowledgements

We would like to offer a special acknowledgement to all patients who participated in the study and investigators for their valuable help in patient recruitment and data collection.

Compliance with ethical standards

Disclosures

None.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© International League of Associations for Rheumatology (ILAR) 2018

Authors and Affiliations

  • Anliu Nie
    • 1
  • Chen Wang
    • 2
  • Yuqing Song
    • 1
  • Xia Xie
    • 1
  • Hui Yang
    • 1
  • Hong Chen
    • 1
  1. 1.West China School of Nursing and Department of Nursing, West China HospitalSichuan UniversityChengduChina
  2. 2.Operation Unit, West China HospitalSichuan UniversityChengduChina

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